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Patent Watch: Canon, Seegene, Gen-Probe, Abbott, Life Tech, and Others Win US Patents

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Canon US Life Sciences has been awarded US Patent No. 8,058,054, "Systems and methods for real-time PCR."

Gregory Owen, Gregory Dale, Kenton Hasson, Shulin Zeng, Dwayne Warfield, and Sarah Warfield are named as inventors on the patent.

Provides a system and methods for the real-time amplification and analysis of a sample of DNA. According to the patent's claims, the invention comprises a microfluidic device that contains a microfluidic channel with a PCR zone and a DNA melting zone, and thus can perform real-time PCR and DNA melting analysis.


Seegene has been awarded US Patent No. 8,058,032, "Method for amplifying unknown DNA sequence adjacent to known sequence."

Jong-Yoon Chun is named as inventor on the patent.

Relates to a method for amplifying an unknown nucleotide sequence adjacent to a known nucleotide sequence. The method comprises performing a primary amplification of the unknown nucleotide sequence using a DNA walking annealing control primer, or DW-ACP, and a first target-specific primer. This primary amplification step more specifically comprises performing a first-stage amplification of the unknown nucleotide sequence at a first annealing temperature. This step comprises at least one cycle of primer annealing, primer extending, and denaturing using a first degenerate DW-ACP containing a degenerate random nucleotide sequence to hybridize with the unknown nucleotide sequence; and a hybridizing nucleotide sequence substantially complementary to a site on the unknown nucleotide sequence. The method subsequently involves performing a second-stage amplification at a second annealing temperature to cause the first degenerate DW-ACP not to function as a primer.


Bioneer has been awarded US Patent No. 8,058,007, "Cyclic reverse transcription method."

Hui Jeong Jeong, Min-Jung Kim, Hae-Joon Park, and Han Oh Park are named as inventors on the patent.

Discloses a cyclic reverse transcription method that comprises performing a reverse transcription reaction in one or more cycles, each cycle comprising the steps of: (a) performing a reaction with a reverse transcription reaction solution comprising template RNA, RNA-dependent DNA polymerase, a reaction buffer, primers for reverse transcription, dNTPs and, optionally, a stabilizer, at 10° to 40° C; and (b) performing a reaction with the resultant reaction solution at 42° to 55° C.


Gen-Probe has been awarded US Patent No. 8,058,006, "Method for obtaining and initiating amplification of a target nucleic acid sequence."

Vivian Jonas is named as inventor on the patent.

Relates to oligonucleotides useful for determining the presence of Mycobacterium tuberculosis complex organisms in a test sample. The oligonucleotides may be incorporated into detection probes, helper probes, capture probes, and amplification oligonucleotides, and used in various combinations thereof.


Honeywell International has been awarded US Patent No. 8,058,005, "Method for single nucleotide polymorphism and mutation detection using real-time polymerase chain reaction microarray."

Zhen Hong Sun, Tao Pan, Wendy Wang, and Hang Liao are named as inventors on the patent.

Describes a method and apparatus for real-time, simultaneous, qualitative measurement of one or more SNPs in one or more target nucleic acids. This method involves combining a PCR technique with an evanescent wave technique.


Forensic Science Service has been awarded US Patent No. 8,057,994, "Investigation of DNA samples."

Martin Bill and Ricky Young are named as inventors on the patent.

Provides a method of investigating a DNA sample that involves taking at least two sub-samples from the sample; amplifying the sub-samples; analyzing the sub-samples to identify and quantify one or more alleles indicated as present in the sub-samples with respect to five or more loci; and establishing identity information deemed representative of the sample from the sub-samples.

The method allows useful profiles to be obtained more often than they are currently, with reduced costs, expertise, and time requirements, the patent's abstract states.


Ibis Biosciences(Abbott) has been awarded US Patent No. 8,057,993, "Methods for identification of coronaviruses."

David Ecker, Steven Hofstadler, Rangarajan Sampath, Lawrence Blyn, Thomas Hall, and Christian Massire are named as inventors on the patent.

Provides a method for rapid identification and quantitation of bacteria by amplification of a segment of bacterial nucleic acid followed by analysis by mass spectrometry. The compositions provide for characterization of the molecular masses and base compositions of bacterial nucleic acids, which are used to rapidly identify bacteria.


Life Technologies has been awarded US Patent No. 8,055,452, "Identification, monitoring, and treatment of disease and characterization of biological condition using gene expression profiles."

Michael Bevilacqua, John Cheronis, Victor Tryon, and Daunte Bankaitis-Davis are named as inventors on the patent.

Describes a method that provides an index of the biological condition of a subject based on a sample from the subject. An embodiment of the method includes deriving from the sample a profile data set that includes a plurality of members, each member being a quantitative measure of the amount of a distinct RNA using amplification, or a protein constituent, in a panel of constituents selected such that their measurement enables evaluation of the biological condition.

The method also involves achieving such measure for each constituent under conditions that are substantially repeatable; and applying values from the profile data set to an index function that allows mapping from an instance of a profile data set into a single-valued measure of biological condition, so as to produce an index pertinent to the biological condition of the subject.

The Scan

Shape of Them All

According to BBC News, researchers have developed a protein structure database that includes much of the human proteome.

For Flu and More

The Wall Street Journal reports that several vaccine developers are working on mRNA-based vaccines for influenza.

To Boost Women

China's Ministry of Science and Technology aims to boost the number of female researchers through a new policy, reports the South China Morning Post.

Science Papers Describe Approach to Predict Chemotherapeutic Response, Role of Transcriptional Noise

In Science this week: neural network to predict chemotherapeutic response in cancer patients, and more.