NEW YORK (GenomeWeb) – Researchers at New England Biolabs have used Pacific Biosciences' Single Molecule Real-Time (SMRT) sequencing to examine sources of error caused by PCR, showing a low error rate can persist even with high-fidelity polymerases.

The NEB scientists plan to use the data to help them better understand the enzymes they create in the future and to give customers a more complete picture of errors that can happen in the PCR amplification step prior to sequencing.

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