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IP Watch: WaferGen, Oxitec, and Wallac Win US Patents


WaferGen has been awarded US Patent No. 8,252,581, "Apparatus for high-throughput chemical reactions."

Victor Joseph, Amjad Huda, and Alnoor Shivji are named as inventors on the patent.

Covers an apparatus, systems, chips, and methods of performing a large number of simultaneous chemical reactions. The chips comprise addressable units that can be addressed according to the temperature of the reaction to be run. The apparatus, systems, and chips are particularly suited for performing PCR on thousands of nucleic acid sequences, up to and including sequences of an entire genome of an organism of interest.

Oxitec of Oxford, UK, has been awarded US Patent No. 8,252,558, "Methods for amplifying and detecting nucleic acid sequences."

Guoliang Fu is named as inventor on the patent.

Provides fast and sensitive nucleic acid amplification and detection methods. More specifically, the patent discloses amplification methods employing different combinations of primers to achieve exponential amplification and strand displacement, such as to generate a more-than-two-fold increase of the amount of a target nucleic acid sequence during repeated cycles, while additionally permitting the production of single-stranded products. The patent also provides detection systems and kits.

Wallac of Turku, Finland, has been awarded US Patent No. 8,252,536, "Integrated nucleic acid analysis."

Pia Ollikka and Alice Ylikoski are named as inventors on the patent.

Relates to an integrated method of nucleic acid analysis, and more particularly to a simplified sample pre-treatment that renders the method more easily automated, where the sample is provided on or applied onto a solid matrix and the subsequent amplification and detection steps are performed in one single, sealed reaction vial without removing the matrix.

The Scan

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

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The portal, described in Nature Genetics, houses variant-related messenger RNA splicing insights drawn from RNA sequencing data in nearly 335,700 samples — a set known as the 300K-RNA resource.

Automated Sequencing Pipeline Appears to Allow Rapid SARS-CoV-2 Lineage Detection in Nevada Study

Researchers in the Journal of Molecular Diagnostics describe and assess a Clear Labs Dx automated workflow, sequencing, and bioinformatic analysis method for quickly identifying SARS-CoV-2 lineages.

UK Team Presents Genetic, Epigenetic Sequencing Method

Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers.