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IP Watch: Recent Patents Related to PCR, Nucleic Acid Amplification, and Sample Prep: Mar 23, 2011

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Roche has been awarded US Patent No. 7,910,720, "Polyanion for improved nucleic acid amplification."

Waltraud Ankenbauer, Dieter Heindl, Frank Laue, Eva Walter, and Renate Kolb are named as inventors on the patent.

The invention is directed to a novel chemical compound that can be used as a suitable hot-start additive for PCR-based amplification of nucleic acids.


Toshiba and Sekisui Medical have been awarded US Patent No. 7,910,719, "Method of detecting human papillomavirus by using nucleic acid amplification method and nucleic acid chain-immobilized carrier."

Koji Hashimoto, Keiko Ito, Naoko Nakamura, Hideki Horiuchi, Michie Hashimoto, and Osamu Sato are named as inventors on the patent.

Provides a nucleic acid primer and method for loop-mediated isothermal amplification, or LAMP, for detecting human papillomavirus and identifying its genotype. The method includes a step of amplifying the nucleic acid chains with LAMP by using multiple primers, including at least one primer selected from the nucleic acid primers provided in the invention; and a step of detecting the presence of amplified products after the amplification reaction and identifying their genotypes.


Complete Genomics has been awarded US Patent No. 7,910,302, "Efficient arrays of amplified polynucleotides."

Radoje Drmanac and Matthew Callow are named as inventors on the patent.

Provides methods, compositions, and systems for the analysis of polynucleotides, particularly polynucleotides derived from genomic DNA. Included are arrays of polynucleotides in which the polynucleotides have undergone multiple rounds of amplification in order to increase the strength of signals associated with single polynucleotide molecules.


Orion Genomics has been awarded US Patent No. 7,910,296, "Methods for quantitative determination of methylation density in a DNA locus."

Jeffrey Jeddeloh and Nathan Lakey are named as inventors on the patent.

Provides a method of determining the average DNA methylation density of a locus of interest within a population of DNA fragments.


The John Wayne Cancer Institute has been awarded US Patent No. 7,910,295, "Detection of micro metastasis of melanoma and breast cancer in paraffin-embedded tumor draining lymph nodes by multimarker quantitative RT-PCR."

Dave Hoon and Hiroya Takeuchi are named as inventors on the patent.

Provides a quantitative real-time reverse-transcriptase PCR assay for detecting metastatic breast, gastric, pancreas, or colon cancer cells or metastatic melanoma. The assay can predict disease recurrence and survival in patients with AJCC stage I, II, and III disease using multimarker panels. The method for detecting metastatic melanoma cells uses panels of markers selected from a group consisting of MAGE-A3, GalNAcT, MART-1, PAX3, Mitf, TRP-2, and tyrosinase. The method for detecting metastatic breast, gastric, pancreas, or colon cancer cells in paraffin-embedded samples utilizes panels of markers selected from a group consisting of C-Met, MAGE-A3, stanniocalcin-1, mammoglobin, HSP27, GalNAcT, CK20, and β-HCG.


Norchip has been awarded US Patent No. 7,910,294, "Ligand detection method."

Frank Karlsen is the sole inventor listed on the patent.

Discloses a sensitive method for specific detection of ligands comprising the steps of (a) contacting the sample with reagents capable of forming a reagent complex, the complex comprising a receptor capable of specifically binding to said ligand and a nucleic acid molecule; and (b) detecting any complexes formed by binding of the receptor part of said reagent complex to ligand present in the sample. Specifically the presence of the nucleic acid molecule is detected by amplifying a region of the nucleic acid and simultaneously detecting products of the amplification reaction in real time.

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.