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IP Watch: Recent Patents Related to PCR, Nucleic Acid Amplification, and Sample Prep: May 24, 2011

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Becton Dickinson has been awarded US Patent No. 7,947,820, "Detection of herpes simplex virus types 1 and 2 by nucleic acid amplification."

David Wolfe, Christine Martinaitis, and Daretta Yursis are named as inventors on the patent.

Relates to a method of detecting the presence or absence of herpes simplex virus in a sample based on amplifying a portion of the glycoprotein G (US4) gene of HSV and detecting the presence of the amplified nucleic acid using primers and detector primers described in the patent. The method further identifies the type of HSV, either HSV-1 or HSV-2, in a sample. The patent also discloses a kit comprising the primers and detector primers that may be used with the amplification method.


Applied Biosystems (Life Technologies) has been awarded US Patent No. 7,947,477, "Emulsion PCR and amplicon capture."

Benjamin Schroeder is named as inventor on the patent.

Discloses compositions and methods of use for clonally amplifying target polynucleotide sequences in solution and attaching the amplicons to a surface by activation of a masked binding moiety. In one embodiment, the amplicons comprise the masked binding moiety and the surface comprises a binding partner of the binding moiety. Upon activation of the binding moiety, the amplicons bind to the binding partner on the surface. In a non-limiting example, the masked binding moiety is caged biotin or caged fluorescein, while the corresponding binding partner is avidin or an anti-fluorescein antibody.


The UK Secretary for the State for Defence has been awarded US Patent No. 7,947,476, "Analytical method and kit."

David Squirrell and Alan Lee are named as inventors on the patent.

Describes an analytical kit using RNA probes for detecting or analyzing nucleic acid sequences. The probes are contacted with a sample suspected of containing the nucleic acid sequence, and if they form duplexes, they are hydrolyzed. This may be done, for example, during an amplification reaction. AMP generated as a result of the hydrolysis is converted to ATP, which may then be detected using bioluminescent reagents.


Roche Molecular Systems has been awarded US Patent No. 7,947,442, "Apparatus for emitting and detecting light in a nucleic acid amplification reaction."

Roger Iten is named as inventor on the patent.

Provides an apparatus, instrument, and method useful in multiplex PCR applications by permitting short sample-measuring times of many samples combined with high sensitivity.


The University of South Florida has been awarded US Patent No. 7,947,441, "Molecular detection and quantification of Enterococci."

Stacey Patterson and John Paul are named as inventors on the patent.

Discloses a primer pair and probe for the large subunit ribosomal RNA gene of Enterococci for use in a real-time nucleic acid sequence based amplification assay.