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IP Watch: Recent Patents Related to PCR, Nucleic Acid Amplification, and Sample Prep: May 31, 2011

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Institut National de la Sante et de la Recherche Medicale has been awarded US Patent No. 7,951,564, "Primers for amplifying mononucleotide satellite markers."

Richard Hamelin and Nirosha Suraweera are named as inventors on the patent.

Provides a method for evaluating microsatellite instability associated with a tumor. The method entails the steps of amplifying microsatellite loci in a biological sample containing genomic DNA from the tumor and determining sizes of DNA amplification products, wherein at least one microsatellite locus selected from the group consisting of NR 21, NR 22, NR 24, and NR 27 is amplified.


Panomics (Affymetrix) has been awarded US Patent No. 7,951,539, "Two-stage nucleic acid amplification using an amplification oligomer."

Gary McMaster and Yunqing Ma are named as inventors on the patent.

Provides methods, compositions, and systems to detect a nucleic acid of interest in a two-stage amplification. The process begins with a first non-enzymatic accumulation of an amplification oligomer that is the target substrate for a second nucleic acid amplification or assay. Two or more amplification oligomers can be used to allow multiplexed amplifications of two or more nucleic acids of interest with deconvolution based on unique detection signals or unique signal locations.


Affymetrix has been awarded US Patent No. 7,951,534, "Hot start nucleic acid amplification."

Christopher Kubu, Jeannine Muller-Greven, and Robert Moffett are named as inventors on the patent.

Provides methods and compositions for performing nucleic acid duplication and amplification reactions. In the method, a single-stranded nucleic acid-binding protein is selected and provided in a reaction mixture, which is assembled at a low, non-stringent temperature to include all of the necessary reagents for successful nucleic acid duplication or amplification reactions. Incorporating a single-stranded nucleic acid-binding protein into the reaction mixture at low temperature improves the generation of nonspecific products such as amplification products despite the reaction mixture having been fully assembled at a non-stringent temperature.

The Scan

Wolf Howl Responses Offer Look at Vocal Behavior-Related Selection in Dogs

In dozens of domestic dogs listening to wolf vocalizations, researchers in Communication Biology see responses varying with age, sex, reproductive status, and a breed's evolutionary distance from wolves.

Facial Imaging-Based Genetic Diagnoses Appears to Get Boost With Three-Dimensional Approach

With data for more than 1,900 individuals affected by a range of genetic conditions, researchers compared facial phenotype-based diagnoses informed by 2D or 3D images in the European Journal of Human Genetics.

Survey Suggests Multigene Cancer Panel VUS Reporting May Vary Across Genetic Counselors

Investigators surveyed dozens of genetic counselors working in clinical or laboratory settings, uncovering attitudes around VUS reporting after multigene cancer panel testing in the Journal of Genetic Counseling.

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.