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IP Watch: Recent Patents Related to PCR, Nucleic Acid Amplification, and Sample Prep: May 31, 2011

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Institut National de la Sante et de la Recherche Medicale has been awarded US Patent No. 7,951,564, "Primers for amplifying mononucleotide satellite markers."

Richard Hamelin and Nirosha Suraweera are named as inventors on the patent.

Provides a method for evaluating microsatellite instability associated with a tumor. The method entails the steps of amplifying microsatellite loci in a biological sample containing genomic DNA from the tumor and determining sizes of DNA amplification products, wherein at least one microsatellite locus selected from the group consisting of NR 21, NR 22, NR 24, and NR 27 is amplified.


Panomics (Affymetrix) has been awarded US Patent No. 7,951,539, "Two-stage nucleic acid amplification using an amplification oligomer."

Gary McMaster and Yunqing Ma are named as inventors on the patent.

Provides methods, compositions, and systems to detect a nucleic acid of interest in a two-stage amplification. The process begins with a first non-enzymatic accumulation of an amplification oligomer that is the target substrate for a second nucleic acid amplification or assay. Two or more amplification oligomers can be used to allow multiplexed amplifications of two or more nucleic acids of interest with deconvolution based on unique detection signals or unique signal locations.


Affymetrix has been awarded US Patent No. 7,951,534, "Hot start nucleic acid amplification."

Christopher Kubu, Jeannine Muller-Greven, and Robert Moffett are named as inventors on the patent.

Provides methods and compositions for performing nucleic acid duplication and amplification reactions. In the method, a single-stranded nucleic acid-binding protein is selected and provided in a reaction mixture, which is assembled at a low, non-stringent temperature to include all of the necessary reagents for successful nucleic acid duplication or amplification reactions. Incorporating a single-stranded nucleic acid-binding protein into the reaction mixture at low temperature improves the generation of nonspecific products such as amplification products despite the reaction mixture having been fully assembled at a non-stringent temperature.

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