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IP Watch: Qiagen, Roche, Cornell, CDC, Life Tech, Promega, Cepheid Among US Patent Winners


Qiagen has been awarded US Patent No. 8,597,938, "System for providing control reactions for real time RT-PCR ."

Jingping Yang and Li Shen are named as inventors.

Discloses methods and oligonucleotides to be used as internal controls in real time RT-PCR, allowing validation of assay parameters and results. Describes multiple control reaction mixtures and template nucleic acids for increasing reliability and validity of assays, particularly ones done in microtiter plates. These control reaction mixtures help monitor sample quality, contamination by inhibitors or genomic DNA, and suboptimal mRNA purification, to enable accurate and consistent measurement of relative gene expression from multiple samples across multiple PCR runs.

Roche has been awarded US Patent No. 8,592,184, "Nucleic acid amplification in the presence of modified randomers."

Dieter Heindl, Waltraud Ankenbauer, and Frank Laue are named as inventors.

Outlines a thermostable DNA polymerase, deoxynucleotides, a primer oligonucleotide or a pair of amplification primers, and a randomized 5-8 mer oligonucleotide, where the oligonucleotide has a modification with an organic hydrophobic moiety specifically useful for performing hot-start PCR.

Cascade Biosystems has been awarded US Patent No. 8,597,886, "Methods and materials for detecting viral or microbial infections."

Kenneth Smith, Nina Yazvenko, and Mariya Smit are named as inventors.

Provides methods and materials for detecting the presence of target viral or microbial nucleic acid in a variety of sample types from different types of mammals, and for quantifying the amount of target nucleic acid present. Also describes methods for making kits.

The US Centers for Disease Control and Prevention has been awarded US Patent No. 8,592,146, "Real-time PCR point mutation assays for detecting HIV-1 resistance to antiviral drugs."

Jeffrey Johnson and Walid Heneine are named as inventors.

Discloses compositions including primers and probes that are capable of interacting with the disclosed nucleic acids, such as the nucleic acids encoding the reverse transcriptase or protease of HIV. Also provides mixtures of primers and probes for use in RT-PCR and primary PCR reactions, and methods for the specific detection of several mutations in HIV. Mutations in both the reverse transcriptase and the protease of HIV can be detected using the described methods.

Applied Biosystems (Life Technologies) has been awarded US Patent No. 8,597,590, "Systems and methods for multiple analyte detection."

Min Yue, David Liu, Joy Roy, Yuh-Min Chiang, Joon Mo Yang, Dennis Lehto, Charles Vann, Nigel Beard, Ian Harding, John Van Camp, Alexander Dromaretsky, Sergey Ermakov, Mark Oldham, Maryam Shariati, and Umberto Ulmanella are named as inventors.

Describes systems and methods for multiple analyte detection including a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers; a sample introduction channel for each sample chamber; and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate; and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample from flowing out of each chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.

Cornell Research Foundation has been awarded US Patent No. 8,597,891 and 8,597,890, both entitled "Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions."

Francis Barany, Matthew Lubin, George Barany, and Robert Hammer are named as inventors.
The patents relate to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligation detection reaction mixture, amplifying the ligation product to form an amplified ligation product in a PCR mixture, detecting the amplified ligation product, and identifying the target nucleotide sequence. Such coupling of the ligase detection reaction and the

Promega has been awarded US Patent No. 8,598,198, "Nucleic acid binding dyes and uses therefor."

Mark McDougall and Stephen Dwight are named as inventors.

Provides novel compounds and compositions, as well as methods of using them. The compounds can be used, for example, to quantify an amount of double-stranded DNA in a sample subjected to nucleic acid amplification, or for real-time monitoring of a nucleic acid amplification reaction. The compounds and reagents can be provided in a kit, for example, with other reagents and instructions for using them.

BG Research has been awarded US Patent No. 8,597,937, "Reaction apparatus."

David Ward, David Edge, and Nelson Nazareth are named as inventors.

Describes an apparatus for biological or chemical reactions, in particular PCR, which includes a heat removal module adapted to snugly receive a reaction vessel in such a manner as to create good thermal conductivity contact between the module and the vessel. The heat removal module is formed of a thermally conductive material having therein a channel adapted for the flow of a coolant liquid. The heat removal module is constructed with an array of receiving stations for the reception of a corresponding array of reaction vessels.

Cepheid has been awarded US Patent No. 8,592,157, "Method for separating an analyte from a sample."

Kurt Petersen, William McMillan, Lee Christel, Ronald Chang, Farzad Pourahmadi, Jesus Ching, Gregory Kovacs, and Allen Northrup are named as inventors.

An analyte is separated from a fluid sample by introducing the sample into a cartridge having a sample port and a first flow path extending from the sample port. The first flow path includes an extraction chamber containing a solid support for capturing the analyte from the sample. The cartridge has a second flow path for eluting the captured analyte from the extraction chamber, the second flow diverging from the first flow path after passing through the extraction chamber. The sample is forced to flow through the extraction chamber and into a waste chamber, thereby capturing the analyte with the solid support as the sample flows through the extraction chamber. The captured analyte is then eluted from the extraction chamber by forcing an elution fluid to flow through the extraction chamber and along the second flow path.