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IP Watch: Mayo Clinic, GeneNews, UMC Hamburg-Eppendorf, Canon, and Life Tech Win US Patents


Mayo Foundation for Medical Education and Research has been awarded US Patent No. 8,101,362, "Detection of Clostridium difficile."

Franklin Cockerill III, Thomas Smith, Jon Rosenblatt, and Lynne Sloan are named as inventors on the patent.

Provides methods to detect C. difficile in biological samples using real-time PCR. Also provides primers and probes for detecting C. difficile; and articles of manufacture containing such primers and probes.

GeneNews has been awarded US Patent No. 8,101,358, "Method of profiling gene expression in a subject having disease."

Choong-Chin Liew is named as inventor on the patent.

Relates to detecting and measuring gene transcripts in blood. More specifically, describes RT-PCR performed on a drop of blood to detect, diagnose, and monitor diseases using tissue-specific primers; and methods to delineate the sequence and/or quantitate the expression levels of disease-associated genes, enabling an immediate and accurate diagnostic/prognostic test for disease or assessment of the effect of a particular treatment regimen.

University Medical Center Hamburg-Eppendorf has been awarded US Patent No. 8,101,352, "Detection of ESR1 amplification in breast cancer."

Guido Sauter, Ronald Simon, Phillip Stahl, Frederik Holst, Khawla Al-Kuraya, and Christian Ruiz are named as inventors on the patent.

Relates to an in vitro method of identifying whether a tumor resulting from a proliferative breast disease is responsive to anti-estrogen treatment; and identifying whether a candidate patient with a proliferative breast disease is suitable for such treatment. In addition, the invention provides an in vitro method of identifying an individual with a non-cancerous proliferative breast disease who is at risk of developing breast cancer. The invention also provides kits for performing the above methods.

Canon has been awarded US Patent No. 8,101,346, "Identifier and nucleic acid amplification method of verification using the same."

Shinichiro Takahama is named as inventor on the patent.

Provides an identification technique that can consistently maintain a set of information to identify a specimen from the amplification process to the detection of a specific nucleic acid sequence. The method includes placing in an amplifiable region an identifier comprising a base sequence that incorporates decodable information imparted to the specimen. The identifier is amplified together with the specimen, and its presence in the amplification product is detected. Thus, an individual can recognize the individual code of the specimen in the amplification product; identify the specimen from which the amplification product is derived; and simultaneously test whether or not the amplification has been carried out satisfactorily.

Applied Biosystems (Life Technologies) has been awarded US Patent No. 8,101,057, "Concentration and cleanup of nucleic acid samples."

Karl Voss is named as inventor on the patent.

Describes methods and devices for concentration and cleanup of samples containing bio-molecule analytes (e.g., polynucleotides, such as DNA, RNA, and PNA). Various embodiments provide for pH-mediated sample concentration and cleanup of nucleic acid samples with channel devices (e.g., cross-T format and microchannel devices).

The Scan

Genetic Testing Approach Explores Origins of Blastocyst Aneuploidy

Investigators in AJHG distinguish between aneuploidy events related to meiotic missegregation in haploid cells and those involving post-zygotic mitotic errors and mosaicism.

Study Looks at Parent Uncertainties After Children's Severe Combined Immunodeficiency Diagnoses

A qualitative study in EJHG looks at personal, practical, scientific, and existential uncertainties in parents as their children go through SCID diagnoses, treatment, and post-treatment stages.

Antimicrobial Resistance Study Highlights Key Protein Domains

By screening diverse versions of an outer membrane porin protein in Vibrio cholerae, researchers in PLOS Genetics flagged protein domain regions influencing antimicrobial resistance.

Latent HIV Found in White Blood Cells of Individuals on Long-Term Treatments

Researchers in Nature Microbiology find HIV genetic material in monocyte white blood cells and in macrophages that differentiated from them in individuals on HIV-suppressive treatment.