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IP Watch: Life Tech, Roche, Abbott, University of Utah, and Quest Win US Patents


Applied Biosystems (Life Technologies) has been awarded US Patent No. 8,265,883, "Systems and methods for baseline correction using non-linear normalization."

Stephen Gunstream is named as inventor on the patent.

Provides systems and methods for calibrating emission data or other information signals collected during a PCR, amplification reaction, assay, process, or other reaction. Calibration of multiple detectable materials can be achieved during a single cycle or run, or during a plurality of runs of the reaction. A reading from every well, container, or other support region of a sample support does not have to be taken. Interpolation can be used to determine values for emission data or other information signals that were not taken, or are unknown, using detected emission data, or other detected information signals. By calibrating the detected emission data and the interpolated data, a more accurate reading of emission data or information signal can be obtained.

Roche Molecular Systems has been awarded US Patent No. 8,265,879, "Determination of single-peak melting temperature by PCR analogy and double sigmoid equation."

Ronald Kurnik and Thomas Thurnherr are named as inventors on the patent.

Discloses systems and methods for determining melting temperatures for DNA from melt curve data and to quantitatively determine gene amount based on peak height. A PCR analogy is used to perform quantization of an acquired melting curve dataset. The melting curve is transformed using a horizontal flip and a horizontal translation, and a double sigmoid equation is then fit to the data. Inverse translation and inverse horizontal flip transforms are applied to the equation to produce an equation-based solution of the melt curve dataset. The equation-based solution of the melt curve is then used to determine the first derivative (e.g., Tm value) and peak height.

Ibis Bioscience (Abbott) has been awarded US Patent No. 8,265,878, "Method for rapid detection and identification of bioagents."

David Ecker, Richard Griffey, Rangarajan Sampath, Steven Hofstadler, and John McNeil are named as inventors on the patent.

Describes a method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers that hybridize to conserved sequence regions of nucleic acids derived from a bioagent and that bracket variable sequence regions that uniquely identify the bioagent. The result is a "base composition signature," which is then matched against a database of base composition signatures, by which the bioagent is identified.

The University of Utah Research Foundation has been awarded US Patent No. 8,263,392, "Methods and compositions related to continuous flow thermal gradient PCR."

Bruce Gale, Niel Davenport, and Carl Wittwer are named as inventors on the patent.

Discloses compositions and a method for amplifying and detecting nucleic acid sequences based on continuous flow thermal gradient PCR. More specifically, the patent describes a device comprising a microchannel extending from an inlet port to an outlet port; and a heater or heaters for producing a spatial temperature gradient, wherein the microchannel has a heating portion and a cooling portion; each portion of the microchannel has a width; the width of the heating portion is wider than the width of the cooling portion; and the heater or heaters are located adjacent to the transition from the heating portion to the cooling portion.

Quest Diagnostics has been awarded US Patent No. 8,263,330, "Detection of Mycobacterium tuberculosis complex nucleic acids."

Maurice Exner is named as inventor on the patent.

Discloses a method for determining the presence of Mycobacterium tuberculosis complex nucleic acids in a test sample. In particular, regions of the IS6110 preferential locus (ipl) 3'-flanking region of the M. tuberculosis complex genome are amplified and detected. In addition, the patent describes oligonucleotides that can be used as primers to amplify the ipl 3'-flanking region, and probe oligonucleotides.

The Scan

Quality Improvement Study Compares Molecular Tumor Boards, Central Consensus Recommendations

With 50 simulated cancer cases, researchers in JAMA Network Open compared molecular tumor board recommendations with central consensus plans at a dozen centers in Japan.

Lupus Heterogeneity Highlighted With Single-Cell Transcriptomes

Using single-cell RNA sequencing, researchers in Nature Communications tracked down immune and non-immune cell differences between discoid lupus erythematosus and systemic lupus erythematosus.

Rare Disease Clues Gleaned From Mobile Element Insertions in Exome Sequences

With an approach called MELT, researchers in the European Journal of Human Genetics uncovered mobile element insertions in exomes from 3,232 individuals with or without developmental or neurological abnormalities.

Team Tracks Down Potential Blood Plasma Markers Linked to Heart Failure in Atrial Fibrillation Patients

Researchers in BMC Genomics found 10 differentially expressed proteins or metabolites that marked atrial fibrillation with heart failure cases.