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IP Watch: Life Tech, Hologic, National U of Singapore, Others Win US Patents

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Applied Biosystems (Life Technologies) has been awarded US Patent No. 8,572,506, "Visualization tool for qPCR genotyping data."

Gordon Janaway and Evelyn Wing-Sim Chan are named as inventors.

Discloses a method to display qPCR data in which two or more samples are probed, and data are plotted relative to each other. Plots are displayed in response to user defined input to provide dynamic and real-time analysis of genotyping data.


Applied Biosystems has also been awarded US Patent No. 8,569,477, "Method for isolating nucleic acids comprising the use of ethylene glycol multimers."

Erling Finne is named as inventor.

Provides a method of isolating nucleic acid via magnetic beads in the presence of an ethylene glycol multimer whereby soluble nucleic acid is bound to the surface, allowing separation of nucleic acid from samples. Also provides kits.


Gen-Probe (Hologic) has been awarded US Patent No. 8,569,020, "Method for simultaneously performing multiple amplification reactions."

Kelly Ammann, Ralph Burns, Ernest Hansberry, Glenn Horner, Cheryl Jakub, John Kling, Donald Nieglos, Robert Schneider, and Robert Smith are named as inventors.

Outlines a method for detecting nucleic acid in multiple samples in parallel by performing within an analyzer automated nucleic acid extraction via a magnetic mechanism, followed by purification, amplification, probe hybridization, and detection, all without human intervention.


National University of Singapore has been awarded US Patent No. 8,568,982, "Methods of nucleic acid synthesis using particular crowding agents and concentrations."

Michael Raghunath, Ricardo Lareu, and Subramhanya Harve are named as inventors.

Provides a method of nucleic acid synthesis, amplification, or improving efficiency, activity, or stability of at least one nucleic acid-modifying enzyme by carrying out the method in the presence of organic-based macromolecules. Also provided is a method of determining optimum crowding conditions of macromolecules in solution. The organic-based macromolecule is a carbohydrate-based hydrophilic polymer of glucose and/or sucrose, and may be Ficoll 70, Ficoll 400, or a mixture. Also described is a kit with one organic-based hydrophilic macromolecule of neutral surface charge, and optionally a polymerase or nuclease enzyme.


Mount Sinai School of Medicine and Beth Israel Medical Center have been awarded US Patent No. 8,568,980, "Nucleic acids, methods and kits for the diagnosis of DYT6 primary torsion dystonia."

Laurie Ozelius and Susan Bressman are named as inventors.

Describes a dystonia-associated gene THAP1, as well as methods and kits for detecting THAP1 mutations and diagnosing dystonia. The invention also relates gene- and protein/antibody-based therapeutics for treating dystonia.


Philadelphia Health & Education Corporation (Drexel University College of Medicine) has been awarded US Patent No. 8,568,984, "Methods of diagnosing non-urinary tract diseases by detecting aberrant methylation."

Ying-Hsiu Su, Benjamin Song, Janet Song, and Timothy Block are named as inventors.

Provides a method of diagnosing non-urinary tract cancers by detecting aberrant methylation in biomarkers from human urine samples.


The Centers for Disease Control and Prevention of the US Department of Health and Human Services has been awarded US Patent No. 8,568,981, "Probe and method for detection and discrimination of types and subtypes of influenza viruses."

Stephen Lindstrom, Alexander Klimov, Nancy Cox, and Lamorris Loftin are named as inventors.

Provides a method in which a sample suspected of containing a nucleic acid of influenza virus is screened by detecting hybridization between an influenza-specific probe, influenza type- or subtype-specific probe, and an influenza nucleic acid. Probes and primers for the detection, typing, or subtyping of influenza virus are disclosed, as are kits and arrays.

The Scan

UK Moves to Allow Sale of Gene-Edited Food

The UK is moving ahead to allow the sale of gene-edited food in England, Scotland, and Wales, according to New Scientist.

Questions for the Field

Stat News writes that the alleged Buffalo shooter's citation of genetics research raises questions about what the field can do.

Cell Studies on Tumor Evolution in Mouse Model of Lung Cancer, Stereo-seq, Bacteriophage Responses

In Cell this week: tumor evolution tracked in mouse model of lung cancer, organogenesis mapped using Stereo-seq, and more.

Taking Stock of the Stockpile

The US and European countries are evaluating their smallpox vaccine stockpiles as the number of monkeypox cases increases, the Washington Post reports.