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IP Watch: LG Life Sciences, Life Tech, USDHHS, GeneNews, and Others Win US Patents

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LG Life Sciences of Seoul, Korea, has been awarded US Patent No. 8,258,283, "Method for detection of HCV at the real-time PCR with intercalating dye."

Dong Hwan Lee, Jin Seok Kang, Jae Sung Lee, Young Suk Park, and Dong Hyun Kim are named as inventors on the patent.

Relates to a composition for detecting hepatitis C virus by a single-step reaction using specific primers and probes described in greater detail in the patent. The patent also describes a method for detecting HCV by a single-step reaction comprising the steps of obtaining a sample from a subject and amplifying and detecting HCV using the primer and probe; and a kit comprising the primer and probe.


The Korean Ocean Research and Development Institute has been awarded US Patent No. 8,257,953, "Hyperthermophilic DNA polymerase and methods of preparation thereof."

Thirteen individuals are listed as inventors on the patent.

Relates to a hyperthermophilic DNA polymerase and a preparation method thereof. More specifically, the patent provides a novel hyperthermophilic DNA polymerase isolated from a Thermococcus sp. strain, a functional equivalent thereof, a protein having the amino acid sequence thereof, and a preparation method thereof. The DNA polymerase has an elongation ability and fidelity higher than those of prior commercial DNA polymerases, and thus will be useful in precision analysis, precision diagnosis, identification and the like, which require accurate PCR, the patent's abstract states.


Applied Biosystems (Life Technologies) and the US Department of Health and Human Services has been awarded US Patent No. 8,257,925, "Method for detecting the presence of a single target nucleic acid in a sample."

James Brown and Jonathan Silver are named as inventors on the patent.

Provides methods and an apparatus for performing nucleic acid amplification on a miniaturized scale with the sensitivity to determine the existence of a single target nucleic acid molecule. The patent describes a miniaturized assembly whereby a fluid sample can be divided into a plurality of sample portions in retaining wells and the sample fluid can be displaced from open ends of the wells while simultaneously being sealed in the wells. The assembly can form, isolate, and retain fluid samples having volumes of between about one microliter to one picoliter or less, and retain the samples under conditions for thermocycling. The invention also provides an analytical assembly having the means to determine simultaneously the presence in a sample of multiple different nucleic acid target molecules.


GeneNews has been awarded US Patent No. 8,257,922, "Method of profiling gene expression in a subject having Alzheimer's disease."

Choong-Chin Liew is named as inventor on the patent.

Relates to the detection and measurement of gene transcripts in blood. The patent specifically provides an RT-PCR analysis performed on a drop of blood to detect, diagnose, and monitor diseases using tissue-specific primers. The patent also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-associated genes allows for an immediate and accurate diagnostic/prognostic test for disease or the assessment of the effect of a particular treatment regimen.

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.