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IP Watch: Johns Hopkins, Affymetrix, Life Tech, Luminex, Illumina, and BD Win US Patents

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Johns Hopkins University has been awarded US Patent No. 8,288,524, "Molecular diagnosis of bacteremia."

Richard Rothman, Maulik Majmudar, and Charlotte Gayos are named as inventors.

Describes a highly specific assay that can be used to detect bacteremia in the clinical setting. The ubiquitous background endogenous DNA present in all PCR reagents is eliminated using a restriction endonuclease digestion. Universal primers for eubacteria are used for detection, and specific primers or probes for bacterial species can be used to identify species.


Affymetrix has been awarded US Patent No. 8,288,522, "Detection of nucleic acids through amplification of surrogate nucleic acids."

Yuling Luo and Son Bui are named as inventors.

Describes methods for detecting and optionally quantitating one or more target nucleic acids, in which a surrogate nucleic acid is captured to each target nucleic acid, amplified, and detected. The patent also describes compositions, kit, and systems related to the methods.


Applied Biosystems (Life Technologies) has been awarded US Patent No. 8,288106, "Sample preparation for in situ nucleic acid analysis, methods and compositions therefor."

Richard Fekete and Annalee Nguyen are named as inventors.

Describes a sample preparation process and provides methods and compositions for in situ RNA or DNA analysis. The method allows DNA or RNA analysis to be carried out in the same tube or on an aliquot of the prepared sample without centrifugation or extraction. The preparation process can be carried out at room temperature in as little as seven minutes and is amenable to high-throughput processing using manual or robotic platforms.


Luminex has been awarded US Patent No. 8,288,105, "Systems and methods for multiplex analysis of PCR in real time."

Douglas Whitman and Charles Collins are named as inventors.

Provides methods and systems for real-time measurements of PCR with multiplexing capability. Certain embodiments relate to methods and systems that use fluorescently encoded superparamagnetic microspheres to immobilize amplification products during the PCR process, and an imaging chamber of a measurement device that is also capable of controllable thermal cycling for assisting the PCR process.


Illumina has been awarded US Patent No. 8,288,103, "Multiplex nucleic acid reactions."

Arnold Oliphant, John Stuelpnagel, Mark Chee, Scott Butler, Jian-Bing Fan, and Min-Jui Richard Shen are named as inventors.

Discloses a variety of multiplexing methods used to amplify and/or genotype a variety of samples simultaneously. More specifically describes a method for amplifying different target nucleic acid sequences of interest in a sample, each sequence comprising, from 3' to 5': contiguous first, second, and third target domains, wherein the first target domain has a detection position one nucleotide from the 3' terminal base of the second target domain, and the second target domain is at least 100 nucleotides in length.


HandyLab (Becton Dickinson) has been awarded US Patent No. 8,287,820, "Automated pipetting apparatus having a combined liquid pump and pipette head system."

Jeff Williams and Kerry Wilson are named as inventors.

Relates to systems for extracting polynucleotides from multiple samples, particularly biological samples; and to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfluidic systems that carry out PCR on multiple samples of nucleotides of interest within microfluidic channels, and detect those nucleotides. The technology still more particularly relates to automated devices for carrying out pipetting operations, particularly on samples in parallel, consistent with sample preparation and delivery of PCR-ready nucleotide extracts to a cartridge wherein PCR is run.

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.