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IP Watch: Genera Biosystems, Life Tech, USDHHS, Hologic, and Samsung Win US Patents


Genera Biosystems has been awarded US Patent No. 8,278,429, "Oligonucleotide amplification primers for targeting oncogenic HPV."

Daniel Park, Zaheer Khan, and Karl Poetter are named as inventors.

Relates generally to the field of diagnostic and detection assays, and more particularly provides methods and reagents including biochips for detecting the presence of, or distinguishing between, one or more analytes in a sample.

Applied Biosystems (Life Technologies) and the US Department of Health and Human Services have been awarded US Patent No. 8,278,071, "Method for detecting the presence of a single target nucleic acid in a sample."

James Brown and Jonathan Silver are named as inventors.

Describes a method comprising subjecting one or more sample portion(s) to a single amplification step, thereby amplifying a single molecule in the sample portion to a detectable level, and, in some embodiments, then determining whether the sample portion contains at least one molecule of the target nucleic acid. In some embodiments, the sample portion is in a porous sample structure; in a sample chamber that minimizes diffusion of the sample portion; in a sample chamber inside a microcapillary device; or in a sample-retaining means.

Gen-Probe (Hologic) has been awarded US Patent No. 8,278,052, "Tagged oligonucleotides and their use in nucleic acid amplification methods."

Wai-Chung Lam, Kristin Livezey, and Michael Becker are named as inventors.

Provides kits containing tagged oligonucleotides for use in certain nucleic acid amplification methods to desirably reduce or eliminate false positive amplification signals resulting from contaminating biological material, e.g., nucleic acid, that may be present in one or more reagents used in the reaction and/or present in the environment in which the reaction is performed. The kits can be used in purification and/or sterility efforts under less stringent conditions than conventionally needed to reduce or eliminate false positive results in a nucleic acid amplification method.

Samsung Electronics has been awarded US Patent No. 8,278,051, "Method of amplifying a target nucleic acid by rolling circle amplification."

Joo-won Rhee, Young-sun Lee, Kak Namkoong, and Chin-sung Park are named as inventors.

Provides a method of amplifying a nucleic acid using rolling cyclic amplification. The method involves amplifying a nucleic acid together with the formation of a single-strand circular DNA template using rolling cyclic amplification using a reaction solution including two hairpin oligos, a target nucleic acid, a DNA ligase, an endonuclease, a DNA polymerase, and a primer.

The Scan

Study Examines Insights Gained by Adjunct Trio RNA Sequencing in Complex Pediatric Disease Cases

Researchers in AJHG explore the diagnostic utility of adding parent-child RNA-seq to genome sequencing in  dozens of families with complex, undiagnosed genetic disease.

Clinical Genomic Lab Survey Looks at Workforce Needs

Investigators use a survey approach in Genetics in Medicine Open to assess technologist applications, retention, and workforce gaps at molecular genetics and clinical cytogenetics labs in the US.

Study Considers Gene Regulatory Features Available by Sequence-Based Modeling

Investigators in Genome Biology set sequence-based models against observational and perturbation assay data, finding distal enhancer models lag behind promoter predictions.

Genetic Testing Approach Explores Origins of Blastocyst Aneuploidy

Investigators in AJHG distinguish between aneuploidy events related to meiotic missegregation in haploid cells and those involving post-zygotic mitotic errors and mosaicism.