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IP Watch: GE Healthcare, Canon US Life Sciences, Mayo Clinic, Roche, Life Tech Win US Patents


GE Healthcare has been awarded US Patent No. 8,507,662, "Methods and kits for reducing non-specific nucleic acid amplification."

John Nelson, Robert Duthie, Sonali Shah, and Clifford Smith are named as inventors.

Provides methods and kits for efficient amplification of nucleic acids. The methods comprise in vitro amplification of a nucleic acid template employing partially constrained primers having a terminal mismatch primer-dimer structure. The methods also comprise in vitro amplification of a nucleic acid template employing partially constrained primers having nucleotide analogues. The methods enhance efficiency of nucleic acid amplification reactions by reducing non-specific amplification.

Canon US Life Sciences has been awarded US Patent No. 8,507,257, "Combined thermal devices for thermal cycling."

Gregory Dale, Shulin Zeng, and Kenton Hasson are named as inventors.

Relates to systems and methods including a combination of thermal generating device technologies to achieve more efficiency and accuracy in PCR temperature cycling of nucleic samples undergoing amplification.

The Mayo Foundation for Medical Education and Research and Roche Molecular Systems have been awarded US Patent No. 8,507,201, "Detection of Bordetella."

Franklin Cockerill, Robin Patel, Lynne Sloan, Sabine Lohmann, and Ulrike Salat are named as inventors.

Provides methods, primers, probes and articles of manufacture containing such primers and probes to differentially detect Bordetella pertussis and/or Bordetella parapertussis in a biological sample.

Applied Biosystems (Life Technologies) has been awarded US Patent No. 8,507,198, "Compositions and methods of selective nucleic acid isolation."

Douglas Bost and Lawrence Greenfield are named as inventors.

Relates to methods and kits for isolating and/or identifying nucleic acids. In certain embodiments, methods of isolating DNA from a biological sample comprise: selectively binding DNA to a solid phase by contacting the biological sample with the solid phase under conditions which selectively bind DNA; separating the solid phase with the bound DNA from an unbound portion of the biological sample; and isolating the DNA from the solid phase, according to the patent summary.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.