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IP Watch: Exiqon, Third Wave, and Olink among Recent US Patent Awardees

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Exiqon has been awarded US Patent No. 8,080,644, "Oligonucleotide analogues."

Jesper Wengel and Poul Nielsen are named as inventors on the patent.

Relates to novel bicyclic and tricyclic nucleoside and nucleotide analogs, as well as to oligonucleotides comprising such elements. The nucleotide analogs, called locked nucleoside analogs, or LNAs, are able to provide valuable improvements to oligonucleotides with respect to affinity and specificity towards complementary RNA and DNA oligomers. The LNA-modified oligonucleotides and LNAs are useful in a wide range of diagnostic and therapeutic applications, including antisense applications; PCR applications; strand displacement oligomers; as substrates for nucleic acid polymerases; as nucleotide based drugs, et cetera.


Third Wave Technologies has been awarded US Patent No. 8,080,643, "HPV primers."

Joseph King and Angela Hudson are named as inventors on the patent.

Provides methods, kits, and compositions related to human papillomavirus primers, which may be used, for example, in nucleic acid detection assays for use in basic research, clinical research, and to develop clinical detection assays.


The Agency for Science, Technology, and Research and the National University of Singapore have been awarded US Patent No. 8,080,411, "Shallow multi-well plastic chip for thermal multiplexing."

Yubo Miao, Yu Chen, Meng Tit Lim, and Chew Kiat Heng are named as inventors on the patent.

Disposable units in current use for performing PCR are limited by their heat block ramping rates and by the thermal diffusion delay time through the plastic wall as well as by the sample itself, the patent abstract explains. The disclosed invention overcomes this limitation by forming a disposable plastic chip using a simple deformation process wherein one or more plastic sheets are caused, through hydrostatic pressure, to conform to the surface of a suitable mold. After a given disposable chip has been filled with liquid samples, it is brought into close contact with an array of heating blocks that seals each sample within its own chamber, allowing each sample to then be heat treated as desired.


Olink has been awarded US Patent No. 8,080,393, "Methods for production of oligonucleotides."

Jorn Koch, Magnus Stougaard, and Jakob Lohmann are named as inventors on the patent.

Relates to the production of oligonucleotides using rolling circle replication, wherein synthesized multimeric oligonucleotides are reduced to mononucleotides using a nicking cassette. Thus, the invention provides a method to produce oligonucleotides, enabling efficient amplification of oligonucleotides at lengths of up to at least 1,000 nucleotides and in high amounts contained within a nicking cassette.

The Scan

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.

DNA Storage Method Taps Into Gene Editing Technology

With a dual-plasmid system informed by gene editing, researchers re-wrote DNA sequences in E. coli to store Charles Dickens prose over hundreds of generations, as they recount in Science Advances.

Researchers Model Microbiome Dynamics in Effort to Understand Chronic Human Conditions

Investigators demonstrate in PLOS Computational Biology a computational method for following microbiome dynamics in the absence of longitudinally collected samples.

New Study Highlights Role of Genetics in ADHD

Researchers report in Nature Genetics on differences in genetic architecture between ADHD affecting children versus ADHD that persists into adulthood or is diagnosed in adults.