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IP Watch: Canon, NuGen, Qiagen, EliTech, Polyplus Transfection, Others Win US Patents


Canon has been awarded US Patent No. 8,466,272, "Probe set and method for identifying HLA allele."

Mamoru Tsukada has been named as inventor on the patent.

Provides a probe set and method that is useful for identifying each allele of HLA individually. The probe set is composed of probes that cover all of the partial sequences that contain a unique base to each allele, and can be used to identify HLA contained in a specimen.

The Council of Scientific & Industrial Research of New Delhi, India, has been awarded US Patent No. 8,465,951, "Method for simultaneous detection and discrimination of bacterial, fungal, parasitic, and viral infections of eye and central nervous system."

Chintalagiri Rao, Ikunchala Rao, Puppala Ramchander, Hajib Madhavan, Savitri Sharma, Gita Satpathy, and Venkata Ravi Kumar are named as inventors.

Relates to diagnostic methods for identification of the single causative agent or more than one causative agent of ocular and nervous system infections among many probable pathogens, which can cause the infection. The method comprises amplifying specific genes of the pathogens by performing a multiplex PCR assay using specific primer sets further described in the patent; hybridizing the amplified products to complementary DNA sequences immobilized on a solid phase matrix in a multiplex format; and detecting the hybridized products. The pathogens are selected from the group consisting of herpes simplex viruses 1 and 2, cytomegaloviruses, varicella zoster virus, adenoviruses, eubacteria, gram-positive bacteria, gram-negative bacteria, fungi, Mycobacterium tuberculosis, Mycobacterium chelonei, Mycobacterium fortuitum, Toxoplasma gondii, and Chlamydia trachomatis. The invention relates to detection and discrimination of the pathogen among the set of probable pathogens in a single test without resorting to a battery of tests each directed at detecting one pathogen, and aims to provide a syndrome-based diagnostic to replace diagnostics based on detection of individual pathogens.

NuGen Technologies has been awarded US Patent No. 8,465,950, "Global amplification using a randomly primed composite primer."

Nurith Kurn and Shenglong Wang are named as inventors.

Relates to the field of polynucleotide amplification. More particularly, the invention provides methods, compositions and kits for amplifying a multiplicity of different polynucleotide template sequences using a randomly primed RNA/DNA composite primer.

The Belfast Health and Social Care Trust has been awarded US Patent No. 8,465,927, "Detection of Neisseria meningitis by loop-mediated isothermal amplification."

Provides a loop-mediated isothermal amplification assay for detection of meningococcal disease. The test comprises at least one nucleic acid primer set capable of detecting Neisseria meningitides in a LAMP-based molecular test, the primer set being chosen from specific sets listed in detail in the patent. Each assay consists of a primer set including of one pair of forward and reverse inner primers, and forward and reverse outer primers. The assay may also include loop forward and/or loop back primers to accelerate the reaction. N. meningitidesserotypes A, B, C, Y, and W135 can be detected using the assay, the patent's abstract states.

The Hong Kong University of Science and Technology has been awarded US Patent No. 8,465,926, "Method and system for real-time quantification and monitoring of nucleic acid amplification using electroconductive or electrochemically active labels."

I Ming Hsing, Thomas Lee, and Stephen Yeung are named as inventors.

Describes a method and device for real-time electrochemical or electrical monitoring and detection of nucleic acid amplification products, i.e. after each polymerase chain reaction cycle, utilizing electrochemically active or electrically conductive reporter materials. An electric voltage is applied to the electrodes and electric signals are measured during a PCR amplification process in order to quantify the amplified products produced from a sample's nucleic acid(s). The technique is suitable for point-of-use applications, e.g. detecting bioanalytes in remote locations.

Generation Biotech, GenoVision, and Qiagen have been jointly awarded US Patent No. 8,465,925, "Method for nucleic acid isolation and amplification."

Johannes Dapprich, Nancy Murphy, and Christian Korfhage are named as inventors.

Provides methods and compositions for sequence-specific isolation of polynucleotide molecules from nucleic acid populations and subsequent amplification of isolated polynucleotide molecules or fragments thereof.

Sysmex of Hyogo, Japan, has been awarded US Patent No. 8,465,924, "Treatment solution for preparing sample solution for nucleic acid amplification reaction and method for detecting nucleic acid by using treatment solution."

Yasuhiro Otomo, Kazuhiko Takeda, Shigeki Abe, and Kazuki Nakabayashi are named as inventors.

Describes a treatment solution for preparing a sample solution for a nucleic acid amplification reaction. The treatment solution comprises dimethyl sulfoxide and aqueous solvent, and is used in the amplification reaction of a nucleic acid to enable efficient recovery of nucleic acid from a biological sample and effective reduction of inhibitor influence during nucleic acid amplification.

EliTech of Spankeren, The Netherlands, has been awarded US Patent No. 8,465,921, "Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders."

Joel Hedgpeth, Irina Afonina, Igor Kutyavin, Eugeny Lukhtanov, Evgeniy Belousov, and Rich Meyer are named as inventors.

Describes conjugates between a minor groove-binding (MGB) molecule, such as the trimer of 1,2-dihydro-(3H)-pyrrolo[3,2-e]indole-7-carboxylate (CDPI3), and an oligonucleotide that form unusually stable hybrids with complementary target sequences in which the tethered CDPI3 group resides in the minor groove of the duplex. These conjugates can be used as probes and primers. Due to their unusually high binding affinity, conjugates as short as 8-mers can be used as amplification primers with high specificity and efficiency. MGB conjugation also increases the discriminatory power of short oligonucleotides, providing enhanced detection of nucleotide sequence mismatches by short oligonucleotides. The MGB-conjugated probes and primers facilitate various analytic and diagnostic procedures, such as amplification reactions, PCR, detection of single-nucleotide polymorphisms, gene hunting, differential display, fluorescence energy transfer, hydrolyzable probe assays, and others by allowing the use of shorter oligonucleotides with higher specificity and better discriminatory power, the patent's abstract states.

Polyplus Transfection, Centre National de la Recherche Scientifique, and Universite de Strasbourg have jointly been awarded US Patent No. 8,465,920, "Method for hybridizing nucleic acids."

Nathalie Lenne and Patrick Erbacher are named as inventors.

Relates to a method for manipulating, isolating, detecting, or amplifying a target nucleic acid in a sample by hybridization with an oligonucleotide-oligocation conjugate, the composition of which is described in greater detail in the patent's claims.