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IP Update: Recent Patents Related to PCR, Sample Prep, and Nucleic Acid Amplification: Mar 3, 2010

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US Patent No. 7,670,779. Nucleotide mixture for improved nucleic acid amplification performance.

Inventors: Brian Washburn, Douglas Lovern, Hwa-Tang Thomas Wang, and Lawrence Burg

Assignee: BioMerieux

The patent relates to the modifications of amplification buffer used in amplification reactions. The modifications result in a significant improvement in amplification results, according to the patent's abstract. In particular, the patent provides methods and buffers for performing an amplification reaction that include treating a buffer comprising nucleotide triphosphates such that a portion of the nucleotide triphosphates are substituted with nucleotide diphosphates.


US Patent No. 7,670,780. Compositions and methods to detect Candida albicans nucleic acid.

Inventors: James Hogan, Irene Andruszkiewicz, Jennifer Bungo, and Shannon Kaplan

Assignee: Gen-Probe

The patent covers nucleic acid sequences that may be used as amplification oligomers, including primers, capture probes for sample preparation, and detection probes specific for Candida albicans 26S rRNA sequences or DNA encoding 26S rRNA. The patent also includes methods to detect the presence of C. albicans in samples. The methods include in vitro nucleic acid amplification of a 26S rRNA sequence or DNA encoding the 26S rRNA sequence to produce a detectable amplification product.


US Patent No. 7,670,832. System for fluorescence monitoring.

Inventors: Carl Wittwer and Kirk Ririe

Assignees: University of Utah and Idaho Technology

According to the patent's abstract, the invention is directed to devices for performing PCR and monitoring the reaction of a sample comprising a nucleic acid and a fluorescent dye. Illustrative devices comprise a heat exchange component for heating and cooling the sample; a control device for repeatedly operating the heat exchange component to subject the sample to thermal cycling; an excitation source for optically exciting the sample to cause the sample to fluoresce; a photodetector for detecting temperature-dependent fluorescence levels from the sample; and a processor configured to record and process emissions from the fluorescent dye.


US Patent No. 7,670,834. Gas thermal cycler.

Inventors: Adrian Fawcett and Mark Reed

Assignee: Applied Biosystems (Life Technologies)

According to its abstract, the patent relates to an apparatus and method for thermal cycling using a source of cooling gas.

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