Skip to main content
Premium Trial:

Request an Annual Quote

Caliper Inks Another NGS Sample Prep Deal, This Time with NuGen

Premium

Caliper Life Sciences continued its recent foray into sample preparation for next-generation sequencing, announcing today an agreement with NuGen to develop and market automated next-gen sequencing sample prep methods on Caliper's Sciclone NGS workstation.

According to the companies, the deal aims to enable researchers to use NuGen's Ovation and Encore reagents on Caliper's liquid-handling platforms to automate processing of a wide range of sample types, such as nucleic acids extracted from sorted cells, fine needle aspirates, formalin-fixed paraffin-embedded tissue, and other limited and compromised clinical samples.

More specifically, Caliper and NuGen will first co-develop automation scripts for NuGen's Ovation RNA-Seq System and Encore Multiplex System I on the Sciclone workstation. The companies said this will enable end-to-end, high-throughput library construction from as little as 500 pg of total RNA.

Caliper and NuGen said that the combined product is scheduled to be available by the end of March.

NuGen CEO Elizabeth Hutt said in a statement that the combined offering allows customers to work from total RNA, which "reduces the bias inherent in the selection steps, and results in a more complete data set and a more comprehensive understanding of the transcriptome, including non-coding RNAs."

The companies noted that the Sciclone NGS workstation can be integrated with Caliper's LabChip GX analytical QC platform and LabChip XT preparative nucleic acid fragmentation platform.

In October, Caliper inked an agreement under which Illumina was to promote the LabChip XT for sample prep in next-gen sequencing applications on Illumina's Genome Analyzer and HiSeq 2000 platforms. The companies also said at the time that they would co-market the LabChip GX for analyzing size, concentration, and integrity of DNA or RNA for quality control during sample prep (PCR Insider, 10/21/10).

The Scan

Team Tracks Down Potential Blood Plasma Markers Linked to Heart Failure in Atrial Fibrillation Patients

Researchers in BMC Genomics found 10 differentially expressed proteins or metabolites that marked atrial fibrillation with heart failure cases.

Study Points to Synonymous Mutation Effects on E. Coli Enzyme Activity

Researchers in Nature Chemistry saw signs of enzyme activity shifts in the presence of synonymous mutations in a multiscale modeling analysis of three Escherichia coli genes.

Team Outlines Paternal Sample-Free Single-Gene Approach for Non-Invasive Prenatal Screening

With data for nearly 9,200 pregnant individuals, researchers in Genetics in Medicine demonstrate the feasibility of their carrier screening and reflex single-gene non-invasive prenatal screening approach.

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.