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Patent Watch: Feb 27, 2009

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The Massachusetts Institute of Technology has been awarded US Patent 7,494,821, "Fluorescein-based sensors for tracking nitric oxide in live cells."

The inventors listed on the patent are Stephen Lippard and Mi Hee Lim.

According to the abstract, the patent is partially focused on coordination complexes for detecting analytes, and methods of making and using these complexes.


Applera has been awarded US Patent 7,494,819, "Electrochemiluminescence electrode."

The inventors listed on the patent are Dar Bahatt, Timothy Liu, and Zbignew Bryning.

The patent describes a bipolar electrode useful for electrochemiluminescence assays and a method for using this electrode, as stated in its abstract.


Stanford University has been awarded US Patent 7,494,807, "Mammalian megakaryocyte progenitor cell."

The inventors listed on the patent are Thanyaphong Na Nakorn, Toshihiro Miyamoto, and Irving Weissman.

Its abstract states that the patent claims a substantially enriched mammalian hematopoietic cell population that is characterized as a progenitor cell committed to the megakaryocyte lineage. The patent also provides methods for the isolation and culture of these cells. The cell enrichment methods use reagents that specifically recognize CD9 and CD41, in conjunction with other markers expressed on lineage-committed progenitor cells. These cells give rise exclusively to megakaryocytes and platelets, as evidenced by their growth and differentiation in vitro and in vivo.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.