Yale

This Week in PLOS

In PLOS this week: transcriptomic and developmental patterns of filamentous fungi development, cutaneous leishmaniasis diagnosis method, and more.

KDSR mutations prevent skin from sealing in moisture and indicate that stimulating other pathways might help patients.

A study from Yale researchers finds that about a third of new drugs, especially ones with accelerated approval, have safety issues, NPR reports.

The semifinalists will receive $50,000 each to develop prototypes of their concepts for submission in the second phase of the challenge.

Poor, Snubbed Archaea

The Atlantic reports that archaea are often neglected by microbiome studies.

Advantage, But Risk

Yale researchers find that autism risk-linked genes are also associated with increased cognitive ability, according to the Independent.

The multi-center precision medicine trial has matched approximately 700 patients to 24 treatment arms so far, but some arms appear to be falling short of their recruitment goal.

The funding will, in part, support efforts to expand the project's catalog of functional elements and understand their roles in different contexts.

Chemotherapy response appears to be more robust in triple-negative breast tumors with mutations decreasing BRCA1 or BRCA2 expression.

A 7 kiloDalton polypeptide known as "non-annotated P-body dissociating polypeptide," or NoBody, appears to contribute to messenger RNA decapping.

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Helix customers can purchase apps that interpret different aspects of their genome, Technology Review reports.

The New York Times reports that a number of companies and research institutes are pursuing gene therapies.

Salmon with shorter telomeres survive to make the trip back to their river homes, New Scientist reports.

In PLOS this week: vaginal microbiome composition, population patterns of Chagas-carrying Rhodnius ecuadoriensis, and more.