Whitehead Institute
Lung Cancer Metastasis Study Relies on CRISPR-Based Method to Track Single-Cell Lineages
Researchers traced the development of thousands of engineered human lung cancer cells within a mouse model of disease to examine metastasis.
DNA Methylation Editing Rescues Neurons in Fragile X Syndrome
Whitehead Institute researchers were able to restore nearly full FMR1 expression in a fragile X syndrome iPSC cell line.
Broad-Led Study Finds Three New HIV Host Factors, Possible Drug Targets
A genome-wide CRISPR screen has revealed five factors required for HIV infection, but which aren't critical to cell viability, including CD4 and CCR5.
CRISPR Screen Reveals Genes Essential to Toxoplasmosis, Malaria Parasites
A Whitehead Institute-led study has revealed genes essential to one-celled parasites causing human diseases, which have resisted gene-editing techniques.
CRISPR Use in Cancer Research, Searching for Druggable Targets Discussed at AACR
At one panel of the AACR conference in New Orleans this week, researchers discussed their labs' efforts to develop screens using CRISPR.