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Wellcome Sanger Institute

Scientists have sequenced more than 2,700 distinct strains from the National Collection of Type Cultures, a non-profit biorepository run by Public Health England.

In cases lacking explanatory protein-coding changes, researchers saw an uptick in de novo mutations in conserved, non-coding regulatory elements.

The researchers also found that genes located near these loci were differentially expressed in healthy versus diseased cartilage.

John Sulston Dies

Nobel-winner John Sulston, who also led the British effort to sequence the human genome, has died, BBC News reports.

Sequencing of typhoid fever outbreak samples in Pakistan indicates extensive drug resistance arose when a local multidrug resistance strain acquired a new plasmid.

At PAG, researchers from the Rockefeller University Vertebrate Genome Laboratory outlined sequencing and assembly strategies for phase 1 of the VGP G10K.

By sequencing Vibrio cholerae isolates from Africa and Latin America, investigators got a look at the lineages leading to outbreaks over several decades.

Using MRSA isolates from England, researchers uncovered hospital-specific, community-specific, and overlapping transmission clusters.

Such an atlas could enable investigators to understand how genetic variants impact disease risk, define drug toxicities, improve therapies, and advance regenerative medicine.

Investigators saw muted negative selection against mutations in genomic data for more than 7,600 tumors, while mining positive selection patterns for cancer driver clues.

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Nature News reports that recent proposed changes to the US National Science Foundation have raised concerns about a shift away from the agency's focus on basic research.

Noel Rose, the "father of autoimmunity," has died at 92, the Washington Post reports.

According to CNN, Legionella was discovered in buildings leased by the Centers for Disease Control and Prevention as they reopened following coronavirus pandemic-related closures.

In PLOS this week: genetic analysis of malaria parasite populations in Southeast Asia, genomic surveillance of yellow fever virus in São Paulo, and more.