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Wellcome Sanger Institute

Effect of Sex

Researchers find a number of traits differ by sex and could affect mouse model studies, according to Reuters.

Even in schizophrenia cases lacking intellectual disability, investigators found that rare mutations in genes normally resistant to loss-of-function changes were enriched.

Researchers saw an over-representation of rarer variants in isolated groups when they sequenced thousands of individuals from 10 European populations.

Researchers led by the Wellcome Trust Sanger Institute also reported that combined chromothripsis and amplification might be a driving mechanism of osteosarcoma.

Researchers applied a SNP heritability model called LDAK to genetic data for a range of human traits, uncovering relatively high levels of variance explained by SNPs.

Copy number alterations in red blood cell invasion receptor-related genes that are more common in some African populations appear to protect against severe malaria.

Researchers profiled the genotypes and phenotypes for more than 700 induced pluripotent stem cell lines, uncovering between-individual sources of variation. 

A comparison of unstimulated and stimulated CD4+ T cells from young and old mice in two subspecies showed rising cell-to-cell expression variability with age.

The researchers used SC3 to uncover subclones within samples from patients with pre-malignant tumors.

Researchers found mutations thought to be associated with embryo development and used them to recreate early cellular life in the human body.

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The Washington Post reports that a Russian Academy of Sciences commission has led to the retraction of hundreds of scientific papers.

The Los Angeles Times' Daily Pilot reports the chief executive of Vantari Genetics has pleaded guilty in a kickback scheme.

News 4 Jax reports that a Florida bill to prevent life and long-term care insurers from using genetic information in their coverage decisions has easily passed one committee.

In Science this week: potentially pathogenic mutations found in hematopoietic stem cells from young healthy donors, and more.