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Wellcome Sanger Institute

Investigators saw muted negative selection against mutations in genomic data for more than 7,600 tumors, while mining positive selection patterns for cancer driver clues.

Several studies describe a new Neanderthal genome, Neanderthal sequence effects on human traits, and ancient hunter-gatherer population social structure clues.

Data from hundreds of individuals suggest that the country's populations are genetically diverse, with a long history of genetic isolation and differentiation.

With sequence data for hundreds of advanced breast cancer samples, investigators identified genetic alterations shared with — and distinct from — those in primary tumors.

Investigators sequenced 3,700-year-old Canaanite genomes and compared them to present-day populations to explore the historical people's origin and fate.

Scientists from The Wellcome Trust Sanger Institute, Public Health England, and elsewhere sequenced the genomes of 209 MRSA isolates collected in Europe from 1960 to 1989.

The institute will house the Centre for Genomic Pathogen Surveillance to monitor antibiotic-resistant bacteria worldwide.

Examining more than half of its genome, researchers found the parasite's success is due to stripping its genome down to essential genes.

Effect of Sex

Researchers find a number of traits differ by sex and could affect mouse model studies, according to Reuters.

Even in schizophrenia cases lacking intellectual disability, investigators found that rare mutations in genes normally resistant to loss-of-function changes were enriched.

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A Brazilian-led team of researchers reports it has generated a sugarcane genome assembly that encompasses more than 99 percent of its genome.

Certain plasma proteins could be used to gauge a person's age and whether they are aging well, according to HealthDay News.

GenomeWeb reports that Veritas Genetics is suspending its US operations.

In Science this week: approach to measure microRNA targeting efficiency, strategy to conduct high-throughput chemical screens at single-cell resolution, and more.