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Wellcome Sanger Institute

In Genome Biology this week: genomic sequencing of milkweed bug, benchmark comparison of single-cell RNA sequencing platforms, and more.

Researchers found a potential alternative toxin, as well as antibiotic resistance genes, in a newly-sequenced Vibrio cholerae strain from a British WWI soldier.

The project dovetails with a separate effort to sequence the whole exomes of the samples, the first 50,000 of which became available to researchers this month.

Analyzing mutational signatures in cancer cell lines and xenografts, investigators identified mutagenic processes that do or don't remain active in vitro.

In Nature this week: new CRISPR nuclease described, gut bacteria reference, and more.

Two research groups have cultured and sequenced microbes in fecal samples from healthy volunteers, producing new reference genomes for hundreds of species.

Two new studies found that prenatal whole-exome sequencing could uncover clinically significant variants in an additional 8 to 12 percent of fetuses with structural anomalies.

Researchers saw variants contributing to both ends of the weight spectrum by analyzing thousands of thin, early-onset obese, and population control individuals.

A number of the genes implicated are also the targets of approved therapeutics or of ones under testing.

Researchers identified immune activity changes in first-trimester placenta and decidua samples profiled through single-cell RNA sequencing.

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Rady Children's Institute for Genomic Medicine and Deloitte are looking into the use of drones to transport samples for testing. 

Direct-to-consumer genetic testing firm 23andMe is laying off about 100 people.

Researchers from Northwestern University examined dust for antibiotic-resistance genes, New Scientist reports. 

In Science this week: researchers present a computational method for predicting cellular differentiation state from single-cell RNA sequencing data, and more.