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Wellcome Sanger Institute

Independent research groups have used array and sequencing-based approaches to catalog CNVs in three Asian populations and gain insights into CNV breakpoint patterns in three individuals.

Paired Ends: Mar 16, 2010


David Botstein, Francis Collins, Eric Lander, Leena Peltonen-Palotie, Carl Fuller, Fredrik Dahl

A pair of high-throughput RNA sequencing studies using Yoruban and European HapMap samples reveals the interplay between genetic variation and gene expression, splicing, and regulation.

Two independent research teams have used copy number and other genomic analyses to characterize cancer genomes.

New England Biolabs will supply the Wellcome Trust Sanger Institute with sample prep reagents suited for preparing next-generation sequencing samples and expression libraries.

The scientists said the project illustrates that thorough sequence analyses of cancer genomes can be done quickly, efficiently, and at a low cost outside of the large sequencing centers.

In a paper appearing online today in Science, researchers reported that they have come up with a high-throughput sequencing-based approach for teasing apart relationships between methicillin-resistant Staphylococcus aureus isolates from around the world and within a single health care facility.

The Sanger Institute researchers said the method is reproducible, strand-specific, and produces more accurate sequence data than standard RNA-seq methods without the need for an amplification step.

The study demonstrates the ability of next-gen sequencing technologies to detect chromosomal rearrangements at a level that previous sequencing technologies and cytogenetics could not do.

The two papers indicate that whole-genome short-read sequencing technologies are becoming increasingly important for identifying cancer-causing genes that could eventually lead to better diagnosis and treatment.


A new analysis suggests warming, not the arrival of humans, led to the extinction of the woolly rhinoceros thousands of years ago, the Economist reports.

Chinese health officials uncovered SARS-CoV-2 viral RNA on imported frozen food, but the New York Times reports catching COVID-19 that way would be unlikely.

The UK has ordered 60 million coronavirus vaccine doses from Novavax and 30 million doses from Janssen, according to the Guardian.

In Science this week: machine learning model predicts whether ion channel mutations will cause disease, and more.