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Wellcome Sanger Institute

The Sanger Institute researchers said the method is reproducible, strand-specific, and produces more accurate sequence data than standard RNA-seq methods without the need for an amplification step.

The study demonstrates the ability of next-gen sequencing technologies to detect chromosomal rearrangements at a level that previous sequencing technologies and cytogenetics could not do.

The two papers indicate that whole-genome short-read sequencing technologies are becoming increasingly important for identifying cancer-causing genes that could eventually lead to better diagnosis and treatment.

An international team of researchers led by investigators at the Wellcome Trust Sanger Institute has sequenced and fully analyzed the genomes of a small cell lung cancer and malignant melanoma.

An international research team has used sequencing approaches to identify, and begin characterizing, an antibiotic-resistant Salmonella enterica serotype Typhimurium bacterium behind a recent rash of invasive infections in sub-Saharan Africa.

The Wellcome Trust Sanger Institute for the first time released online its Annual Review, in which it disclosed that it plans to shift how it uses its sequencing capacity and upgrade its IT infrastructure.

Researchers from the International Swine Genome Sequencing Consortium reported today at a Wellcome Trust Sanger Institute meeting that they have completed the draft genome of the domestic pig.

Using array-based methods, researchers have mapped almost 12,000 potential copy number variants in the human genome and developed reference genotypes for almost 5,000 CNVs.

At the Personal Genomes conference at Cold Spring Harbor Laboratory last week, Illumina chief scientist David Bentley presented results from the company's first cancer genome sequencing project.

Following three pilot projects, results of which are currently being analyzed, the project expects to sequence an additional 985 samples at 4x coverage by early 2010. One of the pilots, designed to test three second-generation sequencing technologies, showed that all three produce data that is suitable for the project.

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Rady Children's Institute for Genomic Medicine and Deloitte are looking into the use of drones to transport samples for testing. 

Direct-to-consumer genetic testing firm 23andMe is laying off about 100 people.

Researchers from Northwestern University examined dust for antibiotic-resistance genes, New Scientist reports. 

In Science this week: researchers present a computational method for predicting cellular differentiation state from single-cell RNA sequencing data, and more.