The Wellcome Trust Sanger Institute and the National Health Services' Clinical Genetics Services will analyze the genomes of thousands of children with developmental disorders and birth malformations in the hope of developing diagnostics.
DDN said the Sanger Institute will use the system to store data from the UK10K project, a three-year initiative that began last year and aims to sequence and analyze 10,000 individuals in the UK in order to discover rare genetic variants that are important in human disease.
Combining whole-genome sequencing with social network analysis, researchers were able to determine that a tuberculosis outbreak in British Columbia several years ago was likely not instigated by genetic changes to the pathogen, but was instead likely due to increased usage of crack cocaine in the community.
Earlier this month at the Advances in Genome Biology and Technology conference, several centers — including the Broad Institute, Baylor College of Medicine, the Wellcome Trust Sanger Institute, Cold Spring Harbor Laboratory, the Yale Center for Genome Analysis, and the NIH Intramural Sequencing Center — provided updates on their current sequencing capacity and how they are putting it to use.
A Wellcome Trust Sanger Institute-led team has sequenced and analyzed the genomes of more than 200 isolates from a drug-resistant Streptococcus pneumoniae lineage that emerged in Spain four decades ago.
By sequencing several cancer samples — and screening hundreds of cancer cell lines — researchers from the UK and US have garnered genetic evidence that cancer-related genomic rearrangements sometimes arise through large, lone mutation events.
The work identified 1,461 proteins tied to more than130 brain diseases, suggesting that synaptic proteins may figure more prominently in nervous system disorders than previously thought and could represent promising new targets for drug development.