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Wellcome Sanger Institute

The Wellcome Trust Sanger Institute and the National Health Services' Clinical Genetics Services will analyze the genomes of thousands of children with developmental disorders and birth malformations in the hope of developing diagnostics.

DDN said the Sanger Institute will use the system to store data from the UK10K project, a three-year initiative that began last year and aims to sequence and analyze 10,000 individuals in the UK in order to discover rare genetic variants that are important in human disease.

Combining whole-genome sequencing with social network analysis, researchers were able to determine that a tuberculosis outbreak in British Columbia several years ago was likely not instigated by genetic changes to the pathogen, but was instead likely due to increased usage of crack cocaine in the community.

Earlier this month at the Advances in Genome Biology and Technology conference, several centers — including the Broad Institute, Baylor College of Medicine, the Wellcome Trust Sanger Institute, Cold Spring Harbor Laboratory, the Yale Center for Genome Analysis, and the NIH Intramural Sequencing Center — provided updates on their current sequencing capacity and how they are putting it to use.

The study highlights the potential of next-generation sequencing to identify variants that allow pathogenic bacteria to evade drugs, and could enable the development of new therapies.

New Products: Feb 1, 2011


DNAStar's SeqMan NGen3, Halo Genomics' targeted resequencing kit, NuGen's Ovation Prokaryotic RNA-seq System, and the Sanger Institute's COSMIC version 51

A Wellcome Trust Sanger Institute-led team has sequenced and analyzed the genomes of more than 200 isolates from a drug-resistant Streptococcus pneumoniae lineage that emerged in Spain four decades ago.

By sequencing several cancer samples — and screening hundreds of cancer cell lines — researchers from the UK and US have garnered genetic evidence that cancer-related genomic rearrangements sometimes arise through large, lone mutation events.

The work identified 1,461 proteins tied to more than130 brain diseases, suggesting that synaptic proteins may figure more prominently in nervous system disorders than previously thought and could represent promising new targets for drug development.

Paired Ends: Nov 9, 2010


David Swarbreck, George Church


Russia says its candidate SARS-CoV-2 vaccine has a very high efficacy rate in an initial analysis of clinical trial data, according to the Financial Times.

Wired reports on a microbial analysis of sketches drawn by Leonardo DaVinci.

A new survey explores coronavirus vaccine hesitancy among Black and Latino individuals, the Washington Post reports.

In Nucleic Acids Research this week: the Aging Atlas database, a database of human metagenome-related metadata, and more.