Researchers from the Wellcome Trust Sanger Institute and elsewhere reported online in the American Journal of Human Genetics yesterday that they have tracked down a new risk gene for osteoarthritis.
Using a so-called pairwise sequentially Markovian coalescent model, researchers from the Wellcome Trust Sanger Institute used information in individual human genomes to gain insights into human population history over hundreds of thousands of years.
Researchers from the Wellcome Trust Sanger Institute and elsewhere describe how they used formaldehyde-assisted isolation of regulatory elements to focus in on non-coding SNP involved in platelet function within an open chromatin region in platelet-producing megakaryocyte cells.
In Nature, researchers describe the high-throughput approach that they have used to make conditional knockouts of more than 9,000 genes in mouse embryonic stem cells.
