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Wellcome Sanger Institute

The Wellcome Trust Sanger Institute and the National Health Services' Clinical Genetics Services will analyze the genomes of thousands of children with developmental disorders and birth malformations in the hope of developing diagnostics.

DDN said the Sanger Institute will use the system to store data from the UK10K project, a three-year initiative that began last year and aims to sequence and analyze 10,000 individuals in the UK in order to discover rare genetic variants that are important in human disease.

Combining whole-genome sequencing with social network analysis, researchers were able to determine that a tuberculosis outbreak in British Columbia several years ago was likely not instigated by genetic changes to the pathogen, but was instead likely due to increased usage of crack cocaine in the community.

Earlier this month at the Advances in Genome Biology and Technology conference, several centers — including the Broad Institute, Baylor College of Medicine, the Wellcome Trust Sanger Institute, Cold Spring Harbor Laboratory, the Yale Center for Genome Analysis, and the NIH Intramural Sequencing Center — provided updates on their current sequencing capacity and how they are putting it to use.

The study highlights the potential of next-generation sequencing to identify variants that allow pathogenic bacteria to evade drugs, and could enable the development of new therapies.

New Products: Feb 1, 2011

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DNAStar's SeqMan NGen3, Halo Genomics' targeted resequencing kit, NuGen's Ovation Prokaryotic RNA-seq System, and the Sanger Institute's COSMIC version 51

A Wellcome Trust Sanger Institute-led team has sequenced and analyzed the genomes of more than 200 isolates from a drug-resistant Streptococcus pneumoniae lineage that emerged in Spain four decades ago.

By sequencing several cancer samples — and screening hundreds of cancer cell lines — researchers from the UK and US have garnered genetic evidence that cancer-related genomic rearrangements sometimes arise through large, lone mutation events.

The work identified 1,461 proteins tied to more than130 brain diseases, suggesting that synaptic proteins may figure more prominently in nervous system disorders than previously thought and could represent promising new targets for drug development.

Paired Ends: Nov 9, 2010

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David Swarbreck, George Church

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Discover magazine reports that animal dissections might dissuade students from science careers, but that a firm has developed synthetic frogs for dissections.

In PNAS this week: de novo mutation patterns among the Amish, an alternative RNA-seq method, and more.

Following its departure from the European Union, the UK is to implement a fast-track visa program aimed at attracting scientific talent to Britain, according to BBC News.

ScienceInsider reports that researchers in Brazil are concerned that a creationist was chosen to run the agency that oversees graduate study programs there.