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Wellcome Sanger Institute

In Science this week: sequencing of diverse human genomes gives insight into genetic variation and population history, commentary on data sharing, and more.

Researchers from the Human Genome Diversity Project discovered common genetic variation that is largely restricted to regions of Africa, Oceania, and the Americas.

Bioinformatics firm Next Gen Diagnostics will integrate Fluidigm's Juno microfluidic sample prep system into its workflow for pathogen whole-genome sequencing.

In Science this week: comprehensive cellular map of the human thymus, evidence of admixture between the ancestors of Neanderthals and Denisovan and a 'superarchaic' population.

Members of a large, international consortium tapped into whole-genome sequences from nearly 2,700 tumors to explore coding and non-coding variants contributing to cancer.

In Nature this week: sequencing analysis finds some cells in the lungs of former smokers have mutational burdens that were equivalent to those of never-smokers, and more.

Researchers found that some cells from former smokers had mutational patterns more similar to those from never-smokers, suggesting that quitting at any age can be beneficial.

In Genome Biology this week: chromosome evolution analysis of the giant panda, somatic mutations in healthy tissues, and more.

Two recent CRISPR-Cas9 viability screens in cancer cell lines were concordant across multiple metrics despite significant differences in experimental protocols.

These alterations, which can include hypermethylation of the H19 locus, can crop up during kidney development.

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The Wall Street Journal reports that Russia's announcement of a coronavirus vaccine approval was met with concern as safety testing has not yet been completed.

New Scientist writes there aren't much data available on the accuracy of the two rapid COVID-19 tests the UK plans to roll out.

In PNAS this week: downstream effect of oncoprotein fusion, epigenetic changes influence tRNAs in colon cancer, and more.

Nature News reports that recent proposed changes to the US National Science Foundation have raised concerns about a shift away from the agency's focus on basic research.