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Wellcome Sanger Institute

Based on sequences for hundreds of E. coli ST131 lineage isolates, researchers propose a model that involves negative frequency-dependent selection on accessory parts of the genome.

By sequencing several individuals with unexplained pancreas and brain development problems, investigators identified a recurrent missense mutation in the CNOT1 gene.

Crusader bones, Lebanon

Sequence data for nine Crusaders buried in Lebanon identified individuals with European, Near Eastern, or mixed ancestry, but no lasting genetic effect on the wider population.

In Genome Biology this week: genomic sequencing of milkweed bug, benchmark comparison of single-cell RNA sequencing platforms, and more.

Researchers found a potential alternative toxin, as well as antibiotic resistance genes, in a newly-sequenced Vibrio cholerae strain from a British WWI soldier.

The project dovetails with a separate effort to sequence the whole exomes of the samples, the first 50,000 of which became available to researchers this month.

Analyzing mutational signatures in cancer cell lines and xenografts, investigators identified mutagenic processes that do or don't remain active in vitro.

This Week in Nature

In Nature this week: new CRISPR nuclease described, gut bacteria reference, and more.

Two research groups have cultured and sequenced microbes in fecal samples from healthy volunteers, producing new reference genomes for hundreds of species.

Two new studies found that prenatal whole-exome sequencing could uncover clinically significant variants in an additional 8 to 12 percent of fetuses with structural anomalies.

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The former commissioner of the FDA has returned to the venture capital firm New Enterprise Associates as a special partner on the healthcare investment team.

Astronauts have edited yeast genes on the International Space Station in an experiment designed to show how cells repair themselves in space.

Emory University has found that two of its researchers failed to divulge they had received funds from China, according to the Atlanta Journal-Constitution.

In Science this week: influence of the nuclear genome on human mitochondrial DNA, and more.