Wellcome Sanger Institute
Genetic Analyses Trace How Mutations Accumulate in Cells of the Human Body Over Time
Four new studies have followed somatic mutations that arise in human cells to unravel cell lineages and examine the development of cancer.
Genome, Metagenomic Sequence Data Highlight Microbe Adaptations to Human Guts
In bacteria from the Firmicutes phylum, investigators saw several adaptations to the human gut suspected of influencing microbial abundance and their ability to spread between individuals.
Middle Eastern Genomes Provide Look at Genetic Variation, Population Histories
With phased genome sequences for 137 individuals from eight Middle Eastern populations, investigators found millions of new genetic variants and retraced past population interactions.
The platform is already being used in drug development and could eventually be harnessed to guide therapy selection in at-risk patients.
Nucleic Acids Research Papers on DeepFun, gutSMASH, COVID-19 Data Portal
In Nucleic Acids Research this week: deep learning approach to gauge consequence of non-coding variants, way to predict primary metabolic gene clusters, and more.