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Wellcome Sanger Institute

Researchers saw transcription factor similarities between developing human intestinal cells and cells from pediatric Crohn's disease cases.

At the Association for Molecular Pathology annual meeting, cancer researcher William Hahn talked about efforts to map cancer fitness genes at the genome scale.

The researchers said their analysis of healthcare and exome data identified 285 genes overall that were significantly associated with developmental disorders.

In Genome Biology this week: graph mapping-based approach to find indels in ancient DNA, tool to analyze chromatin interaction data, and more.

Several Treponema sublineages cropped up after a large antibiotic campaign, though sequence data suggests resistance may have arisen only once.

In Science this week: somatic mutation heterogeneity among human bladder samples, and more.

The analysis further discovered that endemic cholera strains in Argentina were more diverse, a finding that could inform outbreak control efforts.

With targeted, exome, and whole-genome sequencing data, investigators saw recurrent driver mutations and heterogeneous mutational signatures in seemingly normal bladders.

This week in Science: Neanderthal Y chromosomes replaced by Homo sapiens Y chromosomes, and more.

Using transcription data from cells and nuclei, the researchers uncovered heterogeneity within cardiac cells and mapped them to particular regions of the heart.

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The Wall Street Journal reports on gaps in COVID-19 testing affecting less affluent urban areas and rural locations.

According to NBC News, new SARS-CoV-2 variants are making it harder for researchers to model the course of the pandemic.

The New York Times reports that experts say President Joe Biden's goal of vaccinating 1 million people a day in the US in the next 100 days is too low a bar.

In Science this week: single-cell lineage tracing technique applied to study lung cancer metastasis, and more.