Wellcome Sanger Institute
Members of the HCA consortium published around 40 new papers outlining their progress in characterizing cellular features across tissues, organs, and other biological systems.
Low-Coverage WGS Study Reveals Perils Faced by 'Hero' Transplanted Blood Stem Cells
Hematopoietic stem cells transplanted from younger donors in their 20s and 30s survive more often than those from older donors, the study found.
Cancer Cell Line Study Reveals Drug Resistance, Sensitivity Mechanisms
Researchers used systematic gene editing and transcriptomics to find treatment response-related variants in drug-treated cancer cell lines, defining four functional variant classes.
Prenatal Skin Atlas Reveals Role of Immune Cells in Development, Repair Processes
Using single-cell RNA sequencing, spatial transcriptomics, and other approaches, researchers assembled a prenatal skin atlas and compared the results to a skin organoid model.
Developmental Disorder Study Reveals Recessive Genetic Contributors in Diverse Populations
Researchers explored the genetics of autosomal recessive developmental disorders in two large, diverse cohorts, linking some 84 percent of cases to known disease genes.