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Wellcome Sanger Institute

In Genome Biology this week: chromosome evolution analysis of the giant panda, somatic mutations in healthy tissues, and more.

Two recent CRISPR-Cas9 viability screens in cancer cell lines were concordant across multiple metrics despite significant differences in experimental protocols.

These alterations, which can include hypermethylation of the H19 locus, can crop up during kidney development.

The project represents the UK portion of a broader initiative to sequence the genomes of all 1.5 million known animals, plants, protozoa, and fungi.

About Those Chips

The dispute regarding the Wellcome Sanger Institute's use of DNA samples from African individuals could weaken trust between researchers and African populations, Science writes.

B-cell receptor sequencing revealed lower-than-usual memory immune cell activity and more in unvaccinated children after measles virus infection.

Researchers documented population structure, ancestry patterns, trait associations, and more with variants found in the genomes of more than 6,400 Ugandans.

Although normal tissues with somatic mutations did not necessarily progress to cancer, researchers saw a jump in mutational burden in samples associated with cancer or cirrhosis.

A South African university has told the Wellcome Sanger Institute to return DNA samples it has from indigenous African communities, The Times reports.

Thousands of parent-child exomes helped researchers identify apparently causative mobile element insertions in a handful of children with developmental disorders.

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Researchers have sequenced the genome of the depth-dwelling giant squid.

Prosecutors have charged a former Drexel University professor with theft for allegedly spending federal grant money on adult entertainment and other unrelated expenses, according to the Philadelphia Inquirer.

 

Chris Collins, a former US representative, has been sentenced to more than two years in prison in an insider trading case involving an Australian biotechnology firm, the New York Times reports.

In PNAS this week: Trypanosoma brucei transcripts, estimate of people at risk of inherited retinal disease, and more.