Wayne State University

This Week in PLOS

In PLOS this week: transcription levels linked to uracil mutations, transcriptomic analysis of medicinal leech, and more.

Variants in CETP-inhibitor and statin target genes helped investigators untangle complex ties between low-density lipoprotein levels and cardiovascular events.

Investigators identified candidate protein markers from aptamer-based proteomic profiles of samples from women with or without late-onset preeclampsia.

Several academic and commercial groups are developing clinical cell-based noninvasive prenatal tests, which could eventually compete with current cell-free NIPTs.

The team has been monitoring changes in host gene expression patterns due to different types of infections, and hopes to develop a diagnostic test.

The grant, worth $1.4 million in its first year, will be used to develop a panel of RNA expression signatures that can diagnose infections in febrile infants.

The five-year grant will support optimizing the use of polymyxin B to treat Gram-negative bacterial infections and identify protein biomarkers of drug-associated toxicity.

Scientists from Wayne State University have found a set of 648 sperm RNA elements that could predict male fertility and help inform couples trying to conceive.

Three collaborators will further explore the clinical usefulness of a TAA panel in early cancer detection and measuring response to cancer immunotherapy.

NEW YORK (GenomeWeb) – A team from Wayne State University and Michigan's Isle Royale National Park have demonstrated the feasibility of using Ion Torrent sequencing to assess microbial community samples being introduced into the environment.

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The New York Times and ProPublica say that many physicians fail to disclose their financial ties when publishing in medical journals.

The Wall Street Journal reports Human Longevity's valuation has dropped by 80 percent.

Science reports that the US National Cancer Institute is cutting its operating budget by 5 percent.

In PLOS this week: similar variants seen in bullbogs, people with Robinow syndrome; ApoE genotypes in African-American, Puerto Rican populations; and more.