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Technology Review reports that animals given large gene therapies doses have suffered fatal side effects.

Expanded Indications

The FDA has expanded the indications for both AstraZeneca's PARP inhibitor Lynparza and Myriad Genetics' BRACAnalysis CDx test, as GenomeWeb reports.

In Nucleic Acids Research this week: Planteome database of reference plant ontologies and other data; algorithm to find rearrangements in cancer genomes; and more.

Penn bioinformaticians are testing REALGAR, an application to simplify searches of GWAS, WGS, RNA-seq, and other test results for wet-lab researchers.

University of Pennsylvania researchers sequenced single mitochondria, which they noted could be used to track the development of mitochondrial disease.

Investigators have established hundreds of patient-derived xenografts, cell lines, and tumor samples, which appear to represent a wide range of melanoma molecular subtypes.

In the African American arm of a new GWAS, a risk variant in the SEMA3A gene was associated with both alcohol dependence disorder and major depressive disorder.

A genome-wide association study involving almost 1,600 African individuals led to diverse skin pigmentation-associated loci with varied effects on the complex trait.

A new set of papers reveals a range of gene expression influencers, identified using thousands of samples collected for the Genotype-Tissue Expression project.

Beyond BRCA

Mutations in other genes like PALB2 also confer breast cancer risk, the Philadelphia Inquirer writes.

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Nature News reports that gene therapy approaches are tackling sickle cell disease, but that the cost of treatment is a concern.

The Washington Post reports that a US Senate committee voted this week to approve the nomination of Stephen Hahn to lead the Food and Drug Administration.

One gene regulates hundreds of others to influence facial development, according to New Scientist.

In Nature this week: resources for single-cell analysis, little overlap in the microRNAs used by Salmonella and Shigella to infect host cells, and more.