UPenn Sequencing-Based MRD Detection in Bone Marrow May Predict ALL Relapse After CAR T-Cell Therapy Researchers looked at relapse-related markers over time in pediatric and young adult acute lymphoblastic leukemia patients after CAR T-cell treatment. COPD Genetic Risk Factors Vary by Patient Sex, Suggests Research Presented at AMIA With the help of an internally self-developed analytics tool, University of Pennsylvania researchers run GWAS to uncover sex-specific genetic associations for COPD risk. UPenn Researcher Wins $250K Grant to Define CTNNA1-Related Gastric Cancer Risks UPenn’s Bryson Katona will use a DeGregorio Family Foundation grant to expand currently limited data available on the CTNNA1 gene. BostonGene, Abramson Cancer Center to Collaborate on Immunotherapy Studies The agreement will support multiple research projects at UPenn, beginning with a study of tumor-specific antigens for personalized cancer vaccine development. Combination of Sequencing, EHR Data Links Genes to Range of Conditions The exome-by-phenome-wide analysis uncovered 21 novel gene-phenotype associations, including genes linked to glaucoma and diabetes. Sep 28, 2020 Alzheimer's Disease Linked to Epigenetic Changes in Multi-Omic Study Aug 31, 2020 New Methods Boost Scale of Single-Cell Gene Expression Dynamics Studies Premium Jul 30, 2020 Heritable Gene Expression in Single Cells Leads to Subpopulations With Marked Behaviors Jul 14, 2020 Genetic Alterations in Cyclin-Dependent Kinases Highlight Potential Cancer Treatment Approach Jun 16, 2020 Multi-Ancestry Type 2 Diabetes Genetic Study Discovers Hundreds of Novel Loci Jun 2, 2020 Evidence for Targeted Treatment Builds in Cancers of Unknown Primary but Randomized Data Pending Premium May 31, 2020 Oncologists Make Progress Toward Showing Utility for Brain Cancer Liquid Biopsy Apr 16, 2020 Multi-Analyte Liquid Biopsy Panel May Aid in Pancreatic Cancer Detection, Staging Premium Apr 15, 2020 Infant Gut Virome Influenced by Breastfeeding, Metagenomic Analysis Finds Mar 19, 2020 Imaging Could Help ID Brain Cancer Patients Eligible for Plasma Testing Premium Mar 6, 2020 CHOP Shares Insights, Experience From Centralized Genomic Medicine Lab Premium Feb 25, 2020 Epic EMR Users Begin Integrating Genomics Data for Clinical Decision Support Premium Nov 20, 2019 Host Expression Provides Treatment Response Clues in Cutaneous Leishmaniasis Oct 30, 2019 Liquid Biopsy Shows Promise in New Brain Cancer Study Oct 8, 2019 Genetics Contributed to Variations in Height Among Ancient Europeans Aug 15, 2019 Germline Genome Editing Governance Weighed by International Commission Premium Jul 2, 2019 Dilated Cardiomyopathy Risk Increased in Only Some With Titin Truncations May 31, 2019 Single-Cell Sequencing Proves Useful for Tracking Drug-Resistant AML Mutation Progression Premium May 1, 2019 Cleft Palate Study Shows Transcription Factor, Enhancer Roles in Related Developmental Processes May 1, 2019 Genetic Variation Influences People's Perception of Odors Load More Breaking News Variant Identified in Amish Population Appears to Protect From Cardiovascular Disease Danaher Prices $1B Offering of Senior Notes Discovery Life Sciences Acquires Contract Research Firm In Vitro ADMET Laboratories Audere Gets FDA Emergency Use Authorization for SARS-CoV-2 At-Home Sample Collection Kit GenomeWeb Index Falls 6 Percent in November as Emergence of Omicron Spooks Markets Sequencing-Based MRD Detection in Bone Marrow May Predict ALL Relapse After CAR T-Cell Therapy The Scan Science Confidence Boost The New York Times reports that a new poll finds trust in science and scientists has increased with the COVID-19 pandemic. Appeal and Funds Some grant applications denied funding due to an Australian Research Council rule change have now been funded following an appeal, the Guardian reports. Surveillance for Variants Vox writes that the detection of the Omicron SARS-CoV-2 variant highlights the need for improved viral genomic surveillance. Nature Papers Examine Taxonomic Gaps in Plant Sequencing, SARS-CoV-2-Human Interactome In Nature this week: plant genome sequencing dominated by affluent countries, and more.