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UPenn

BostonGene, Abramson Cancer Center to Collaborate on Immunotherapy Studies

The agreement will support multiple research projects at UPenn, beginning with a study of tumor-specific antigens for personalized cancer vaccine development.

Combination of Sequencing, EHR Data Links Genes to Range of Conditions

The exome-by-phenome-wide analysis uncovered 21 novel gene-phenotype associations, including genes linked to glaucoma and diabetes.

Alzheimer's Disease Linked to Epigenetic Changes in Multi-Omic Study

Investigators identified disease-associated histone modifications in the brain that appeared to influence transcription- and chromatin-related processes.

New Methods Boost Scale of Single-Cell Gene Expression Dynamics Studies
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Labs are finding cheaper, higher-throughput ways to determine the inflection points in gene expression within a particular cell.

Heritable Gene Expression in Single Cells Leads to Subpopulations With Marked Behaviors

Researchers have developed a method, called MemorySeq, to identify genes transcriptome-wide whose expression fluctuations persist for several cell divisions.

Jul 14, 2020

Genetic Alterations in Cyclin-Dependent Kinases Highlight Potential Cancer Treatment Approach

Jun 16, 2020

Multi-Ancestry Type 2 Diabetes Genetic Study Discovers Hundreds of Novel Loci

Jun 2, 2020

Evidence for Targeted Treatment Builds in Cancers of Unknown Primary but Randomized Data Pending
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May 31, 2020

Oncologists Make Progress Toward Showing Utility for Brain Cancer Liquid Biopsy

Apr 16, 2020

Multi-Analyte Liquid Biopsy Panel May Aid in Pancreatic Cancer Detection, Staging
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Apr 15, 2020

Infant Gut Virome Influenced by Breastfeeding, Metagenomic Analysis Finds

Mar 19, 2020

Imaging Could Help ID Brain Cancer Patients Eligible for Plasma Testing
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Mar 6, 2020

CHOP Shares Insights, Experience From Centralized Genomic Medicine Lab
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Feb 25, 2020

Epic EMR Users Begin Integrating Genomics Data for Clinical Decision Support
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Nov 20, 2019

Host Expression Provides Treatment Response Clues in Cutaneous Leishmaniasis

Oct 30, 2019

Liquid Biopsy Shows Promise in New Brain Cancer Study

Oct 8, 2019

Genetics Contributed to Variations in Height Among Ancient Europeans

Aug 15, 2019

Germline Genome Editing Governance Weighed by International Commission
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Jul 2, 2019

Dilated Cardiomyopathy Risk Increased in Only Some With Titin Truncations

May 31, 2019

Single-Cell Sequencing Proves Useful for Tracking Drug-Resistant AML Mutation Progression
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May 1, 2019

Cleft Palate Study Shows Transcription Factor, Enhancer Roles in Related Developmental Processes

May 1, 2019

Genetic Variation Influences People's Perception of Odors

Apr 2, 2019

Treatment With Less Toxic Rubraca in Molecularly-Defined Pancreatic Cancer Subset Proposed at AACR
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Mar 22, 2019

Spontaneous Preterm Birth Clues Identified in Cervicovaginal Microbiome

Feb 19, 2019

East African Hunter-Gatherer Populations Share Common Genetic Ancestry

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The Scan

For Those Thick Tiger Stripes

Tigers in India with thick stripes harbor a genetic change, as Gizmodo reports.

High GABA Tomatoes

The Japan News reports that genome-edited tomatoes with higher GABA levels are now for sale in Japan.

Approach for Inclusivity and Diversity

A National Human Genome Research Institute team calls for the field to "adopt diversity as an ethos."

Science Papers on Tumors Immune System Evasion; Drivers of Genomic Instability, Inflammation

In Science this week: study of how tumors evade the adaptive immune system, and more.