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Sequencing-Based MRD Detection in Bone Marrow May Predict ALL Relapse After CAR T-Cell Therapy

Researchers looked at relapse-related markers over time in pediatric and young adult acute lymphoblastic leukemia patients after CAR T-cell treatment.

COPD Genetic Risk Factors Vary by Patient Sex, Suggests Research Presented at AMIA

With the help of an internally self-developed analytics tool, University of Pennsylvania researchers run GWAS to uncover sex-specific genetic associations for COPD risk.

UPenn Researcher Wins $250K Grant to Define CTNNA1-Related Gastric Cancer Risks

UPenn’s Bryson Katona will use a DeGregorio Family Foundation grant to expand currently limited data available on the CTNNA1 gene.

BostonGene, Abramson Cancer Center to Collaborate on Immunotherapy Studies

The agreement will support multiple research projects at UPenn, beginning with a study of tumor-specific antigens for personalized cancer vaccine development.

Combination of Sequencing, EHR Data Links Genes to Range of Conditions

The exome-by-phenome-wide analysis uncovered 21 novel gene-phenotype associations, including genes linked to glaucoma and diabetes.

Sep 28, 2020

Alzheimer's Disease Linked to Epigenetic Changes in Multi-Omic Study

Aug 31, 2020

New Methods Boost Scale of Single-Cell Gene Expression Dynamics Studies
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Jul 30, 2020

Heritable Gene Expression in Single Cells Leads to Subpopulations With Marked Behaviors

Jul 14, 2020

Genetic Alterations in Cyclin-Dependent Kinases Highlight Potential Cancer Treatment Approach

Jun 16, 2020

Multi-Ancestry Type 2 Diabetes Genetic Study Discovers Hundreds of Novel Loci

Jun 2, 2020

Evidence for Targeted Treatment Builds in Cancers of Unknown Primary but Randomized Data Pending
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May 31, 2020

Oncologists Make Progress Toward Showing Utility for Brain Cancer Liquid Biopsy

Apr 16, 2020

Multi-Analyte Liquid Biopsy Panel May Aid in Pancreatic Cancer Detection, Staging
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Apr 15, 2020

Infant Gut Virome Influenced by Breastfeeding, Metagenomic Analysis Finds

Mar 19, 2020

Imaging Could Help ID Brain Cancer Patients Eligible for Plasma Testing
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Mar 6, 2020

CHOP Shares Insights, Experience From Centralized Genomic Medicine Lab
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Feb 25, 2020

Epic EMR Users Begin Integrating Genomics Data for Clinical Decision Support
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Nov 20, 2019

Host Expression Provides Treatment Response Clues in Cutaneous Leishmaniasis

Oct 30, 2019

Liquid Biopsy Shows Promise in New Brain Cancer Study

Oct 8, 2019

Genetics Contributed to Variations in Height Among Ancient Europeans

Aug 15, 2019

Germline Genome Editing Governance Weighed by International Commission
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Jul 2, 2019

Dilated Cardiomyopathy Risk Increased in Only Some With Titin Truncations

May 31, 2019

Single-Cell Sequencing Proves Useful for Tracking Drug-Resistant AML Mutation Progression
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May 1, 2019

Cleft Palate Study Shows Transcription Factor, Enhancer Roles in Related Developmental Processes

May 1, 2019

Genetic Variation Influences People's Perception of Odors

Breaking News
The Scan

Science Confidence Boost

The New York Times reports that a new poll finds trust in science and scientists has increased with the COVID-19 pandemic.

Appeal and Funds

Some grant applications denied funding due to an Australian Research Council rule change have now been funded following an appeal, the Guardian reports.

Surveillance for Variants

Vox writes that the detection of the Omicron SARS-CoV-2 variant highlights the need for improved viral genomic surveillance.

Nature Papers Examine Taxonomic Gaps in Plant Sequencing, SARS-CoV-2-Human Interactome

In Nature this week: plant genome sequencing dominated by affluent countries, and more.