Utah's Dana Carroll, UC Berkeley's Jacob Corn, and their colleagues replaced the sickle cell disease mutation with the wild-type gene via HDR.
Frameshift plans to commercialize two applications: one for data quality control and a second for identifying mutations in rare and Mendelian disorders.
The partnership stands to accelerate the Utah Genome Project, which aims to discover new disease-causing genes and advance tests by studying large families.
The researchers said that this property of ctDNA could be exploited to improve the sensitivity of liquid biopsies.
The agency has awarded five-year grants to three research institutions to promote education in genomic medicine among physicians and biomedical scientists.
The new study in NEJM describes six families that share a disorder caused by mutations in IKAROS, a protein that plays a role in immune cell development.
The team said the findings shed light on how new species form and how cancer develops.
The researchers’ method involves the use of third base pair labeling, PCR amplification, and nanopore sequencing.
The results suggest that multiple copies of the tumor suppressor gene TP53 appear to play a role in lower rates of cancer development in elephants.
The court found that the university had failed to demonstrate that one of its researchers had collaborated with the IP's inventors and therefore is not entitled to co-inventorship.
In Nucleic Acids Research this week: ProTraits includes genetic, phenotypic data on bacteria, archaea; Candida albicans assembly 22; and more.
The Wall Street Journal reports that researchers are looking beyond Cas9 for CRISPR editing.
Familial DNA searches in criminal cases are winning over some critics, the Los Angeles Times reports.
In PNAS this week: miR-515 levels higher in women with preeclampsia, horizontal gene transfer in parasitic plants, and more.