A GWAS meta-analysis involving 10,074 PCOS cases revealed three new and 11 known risk loci, along with a relatively consistent genetic architecture among cases.
Researchers used exome data for more than 123,000 individuals to map "constrained coding regions," where disease-related variants are over-represented.
A study of the detection of potential adverse drug events or interactions found that using PGx information led to better prediction of serious issues, despite no significant change overall.
A new study shows that DNA targets bound by nucleosomes are cleaved less efficiently than targets lacking nucleosomes, which could inform target selection.
In Cell this week: sequencing to understand medulloblastoma metastases, genome and transcriptome implicates TAP1 in X-linked Dystonia-Parkinsonism, and more.
Researchers discovered thousands of candidate functional elements by searching diverse mammalian genomes for regions of accelerated evolution within highly conserved sites.
