University of Toronto
Researchers are advancing a multiomic method they hope can improve care for patients who have inherited a dramatic risk of developing cancer.
Team Untangles Mechanism Behind Noncoding Glioma Risk Variant
A SNP on chromosome 8 that increases risk of IDH-mutant low-grade glioma falls in a brain-specific enhancer that alters transcription factor binding and downstream signaling.
Canadian Healthcare Providers, Policymakers Value Different Aspects of Clinical Genomic Sequencing
The disconnect, University of Toronto researchers found, leads some clinicians to seek genome sequencing information through roundabout means.
Early Cancer Detection in Li-Fraumeni Syndrome Patients Enabled by Liquid Biopsy Test
Integrated analysis of cell-free DNA appears to help predict the development of cancer in individuals with the hereditary cancer susceptibility condition.
Candidate Hair Color Variants Identified in Meta-Analysis of Canadian Cohort
The study of more than 12,000 individuals also highlighted biological mechanisms that may affect pigmentation among humans.