University of Toronto
Brain Vasculature Cell Features Spelled Out in Single-Cell Sequencing Atlas
Researchers relied on single-cell RNA sequencing to characterize vascular cell types and molecular markers found in the human brain in different developmental and disease states.
Written by early OGM adopters, the framework describes best practices for the technology's clinical implementation for hematological malignancies.
Cancer Study Finds Protein-Truncating Mutations Overrepresented in Specific Mutational Signatures
Researchers linked stop-gain mutations stemming from smoking, APOBEC enzyme activity, and reactive oxygen species to related mutational signatures, genes, and pathways.
Multimodal Cell-Free DNA Test May Help Detect Cancer Early in Li-Fraumeni Syndrome Patients
Researchers analyzed cfDNA from blood focusing on genomic, fragmentomic, and epigenomic features linked to cancer in individuals with germline TP53 mutations.
Blood Pressure Genetic Variants Linked to Regulatory Functions, Cardiovascular Pathways
Using massively parallel reporter assays and other approaches, researchers explored the functional effects of blood pressure-associated variants and narrowed in on causal variants.