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University of Toronto

Cancer Early Detection Shows Promise in New Li-Fraumeni Syndrome Data
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Researchers are advancing a multiomic method they hope can improve care for patients who have inherited a dramatic risk of developing cancer.

Team Untangles Mechanism Behind Noncoding Glioma Risk Variant

A SNP on chromosome 8 that increases risk of IDH-mutant low-grade glioma falls in a brain-specific enhancer that alters transcription factor binding and downstream signaling.

Canadian Healthcare Providers, Policymakers Value Different Aspects of Clinical Genomic Sequencing

The disconnect, University of Toronto researchers found, leads some clinicians to seek genome sequencing information through roundabout means.

Early Cancer Detection in Li-Fraumeni Syndrome Patients Enabled by Liquid Biopsy Test

Integrated analysis of cell-free DNA appears to help predict the development of cancer in individuals with the hereditary cancer susceptibility condition.

Candidate Hair Color Variants Identified in Meta-Analysis of Canadian Cohort

The study of more than 12,000 individuals also highlighted biological mechanisms that may affect pigmentation among humans.

Oct 25, 2021

Single-Cell Tumor Classifier Algorithm Unveiled at ASHG, Provides Tissue of Origin

Feb 19, 2021

Researchers Aim to Improve Lynch Syndrome Testing With Genetic-Epigenetic Combination Method
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Nov 18, 2020

CNV Analyses May Uncover Mendelian Conditions in Undiagnosed Pediatric Patients

Nov 2, 2020

Researchers Turn Methylated DNA Profiling Method Towards Prenatal Testing Applications
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Oct 26, 2020

Cellular Analytics Eyes Early Mesothelioma Detection Using Liquid Biopsy Tech
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Sep 23, 2020

CRISPR Screen Uncovers Genes That Help Cancer Cells Evade Immune System

Jun 26, 2020

Brain, Kidney Cancer Studies Lay Path for Clinical Application of Epigenetic Liquid Biopsy Method
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Apr 13, 2020

Pediatric Low-Grade Glioma Molecular and Clinical Analysis Defines Subtypes That Predict Outcome

Apr 8, 2020

Tens of Thousands of Protein-Protein Interactions Reported in Human Reference Interactome Map

Mar 18, 2020

CRISPR Screening Approach for Mapping Genetic Interactions Uncovers Masked Phenotypes

Mar 12, 2020

Head and Neck Cancer Driver Mutations Affect NOTCH Pathway, CRISPR Screen Finds

Feb 5, 2020

Large-Scale Pan-Cancer Analysis Expands Set of Alterations Disrupting Key Genes, Pathways

Jan 7, 2020

Circulating Tumor Cell Collection, Analysis Methods Make Headway in 2019
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Dec 12, 2019

Online Tool to Select Secondary Findings May Shorten Genetic Counseling Sessions

Nov 6, 2019

Cellular Analytics Eyes Drug Development Space with Circulating Tumor Cell Capture Platform
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Oct 7, 2019

Prostate Cancer Methylation Levels Linked to Regulatory Variants in Germline

May 3, 2019

Differential Methylation of Enhancer May Lead to Abnormal Dopamine Levels in Major Psychosis

Feb 7, 2019

Cancer-Associated Circular RNAs Catalogued Across Tumor Types

Feb 4, 2019

Genome Canada, Partners Award $42.6M in Genomics, Informatics Research Funding

Jan 14, 2019

Risky Behavior Tied to Hundreds of Loci Through Large GWAS Analysis

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The Scan

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.

SpliceVault Portal Provides Look at RNA Splicing Changes Linked to Genetic Variants

The portal, described in Nature Genetics, houses variant-related messenger RNA splicing insights drawn from RNA sequencing data in nearly 335,700 samples — a set known as the 300K-RNA resource.

Automated Sequencing Pipeline Appears to Allow Rapid SARS-CoV-2 Lineage Detection in Nevada Study

Researchers in the Journal of Molecular Diagnostics describe and assess a Clear Labs Dx automated workflow, sequencing, and bioinformatic analysis method for quickly identifying SARS-CoV-2 lineages.

UK Team Presents Genetic, Epigenetic Sequencing Method

Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers.