University of Toronto Researchers Aim to Improve Lynch Syndrome Testing With Genetic-Epigenetic Combination Method Premium The sequencing test involves a single library preparation that is then split for parallel analysis of promoter methylation, MSI calculation, and gene mutation detection. CNV Analyses May Uncover Mendelian Conditions in Undiagnosed Pediatric Patients Investigators diagnosed additional Mendelian conditions with copy number variant analyses on pediatric patients who remained undiagnosed after exome sequencing. Researchers Turn Methylated DNA Profiling Method Towards Prenatal Testing Applications Premium At the ASHG 2020 virtual meeting, researchers presented data showing they could use the method to enrich for placental DNA in maternal plasma samples. Cellular Analytics Eyes Early Mesothelioma Detection Using Liquid Biopsy Tech Premium The firm's assay, dubbed MesoFind, uses an immunomagnetic capture method to identify surface antigens on mesothelioma pleural cells in a patient's blood sample. CRISPR Screen Uncovers Genes That Help Cancer Cells Evade Immune System Autophagy-associated genes appear to be important for immune evasion, but losing multiple of these genes could also make cancers resistant to T cell activity. Jun 26, 2020 Brain, Kidney Cancer Studies Lay Path for Clinical Application of Epigenetic Liquid Biopsy Method Premium Apr 13, 2020 Pediatric Low-Grade Glioma Molecular and Clinical Analysis Defines Subtypes That Predict Outcome Apr 8, 2020 Tens of Thousands of Protein-Protein Interactions Reported in Human Reference Interactome Map Mar 18, 2020 CRISPR Screening Approach for Mapping Genetic Interactions Uncovers Masked Phenotypes Mar 12, 2020 Head and Neck Cancer Driver Mutations Affect NOTCH Pathway, CRISPR Screen Finds Feb 5, 2020 Large-Scale Pan-Cancer Analysis Expands Set of Alterations Disrupting Key Genes, Pathways Jan 7, 2020 Circulating Tumor Cell Collection, Analysis Methods Make Headway in 2019 Premium Dec 12, 2019 Online Tool to Select Secondary Findings May Shorten Genetic Counseling Sessions Nov 6, 2019 Cellular Analytics Eyes Drug Development Space with Circulating Tumor Cell Capture Platform Premium Oct 7, 2019 Prostate Cancer Methylation Levels Linked to Regulatory Variants in Germline May 3, 2019 Differential Methylation of Enhancer May Lead to Abnormal Dopamine Levels in Major Psychosis Feb 7, 2019 Cancer-Associated Circular RNAs Catalogued Across Tumor Types Feb 4, 2019 Genome Canada, Partners Award $42.6M in Genomics, Informatics Research Funding Jan 14, 2019 Risky Behavior Tied to Hundreds of Loci Through Large GWAS Analysis Jan 2, 2019 Circulating Tumor Cell Capture Technologies Expand in 2018 Premium Nov 21, 2018 Immunoprecipitation Method Could Improve Epigenetic Early Cancer Detection Tests Premium Nov 14, 2018 Methylation-Based Cancer Early Detection Method Shows Promise in Preliminary Studies Sep 17, 2018 NGS-Based Post-Transplant Acute Myeloid Leukemia Assay Predicts Relapse Risk Premium Aug 30, 2018 Subset of Ewing Sarcomas Arise from Early, Complex Genome Rearrangements Apr 6, 2018 Researchers Debut Method for Combined Separation, Gene Expression Analysis of CTCs Premium Load More Breaking News Alzheimer's Disease Phosphoproteomics Study Uncovers Signaling Abnormalities Genetic Analysis of H. Pylori Indicates Americas Colonized in One Main Migration Event BillionToOne Raises $55M in Series B Financing GeninCode to Launch Cardiovascular Disease Risk Tests in US With Eversana Top Five Articles on GenomeWeb Last Week: Illumina, Liquid Biopsy, Thermo Fisher Scientific, and More Becton Dickinson Sues Beckman Coulter Over Cell Analysis, Sorting IP The Scan Another Resignation According to the Wall Street Journal, a third advisory panel member has resigned following the US Food and Drug Administration's approval of an Alzheimer's disease drug. Novavax Finds Its Vaccine Effective Reuters reports Novavax's SARS-CoV-2 vaccine is more than 90 percent effective in preventing COVID-19. Can't Be Used The US Food and Drug Administration says millions of vaccine doses made at an embattled manufacturing facility cannot be used, the New York Times reports. PLOS Papers on Frozen Shoulder GWAS, Epstein-Barr Effects on Immune Cell Epigenetics, More In PLOS this week: genome-wide association study of frozen shoulder, epigenetic patterns of Epstein-Barr-infected B lymphocyte cells, and more.