Autophagy-associated genes appear to be important for immune evasion, but losing multiple of these genes could also make cancers resistant to T cell activity.
Investigators reported that methylation profiling could distinguish brain cancer subtypes and could detect kidney cancer with striking sensitivity in early experiments.
In PLOS this week: genome-wide association study of agronomic traits in sugarcane, breastfeeding can modulate body-mass index among individuals at genetic risk of obesity, and more.
The study suggests that pediatric low-grade gliomas driven by genetic rearrangements tend to be diagnosed earlier and have better outcomes than those driven by SNVs.
In Nature this week: three-dimensional assay to visualize transposase-accessible chromatin, computational tool that uses variant information to map cells to clone of origin, and more.
The screen, which multiplexes Cas9 and Cas12a, could be used for functional analysis of large genomic regions in mammalian cells, the researchers said.
