The researchers showed that Cas12a discriminates strongly against mismatches to DNA targets, leading to less off-target DNA cleavage than with Cas9.
In PNAS this week: interactions between tRNA precursor and tumor-suppressing microRNA, sequencing strategy to account for small indels in DNA barcodes, and more.
Speakers at the Association for Biomolecular Resource Facilities annual meeting gave advice on preparing for and recovering from hurricanes.
One team suggested Cas4 is required to assist the Cas1-2 complex, while the other said Cas4 helps maintain fidelity during CRISPR adaptation.
The grants were made as part of the NSF's Enabling Discovery through Genomic Tools — or EDGE — program.
Researchers tracked one individual's brain imaging patterns, physical features, blood metabolomics, gene expression, and more.
The two-year award comes on the heels of the publication of a map of the Upland cotton genome by US and Chinese researchers.
A transcriptome sequencing study from researchers at the University of Texas has identified new gene co-expression networks associated with alcoholism.
NEW YORK (GenomeWeb) – In Nature Genetics, an international team led by investigators at the National Institute on Aging presented findings from a meta-analysis of Parkinson's disease genome-wi
NEW YORK (GenomeWeb) – Two research teams reported on mutational patterns present in gastric cancer in Nature Genetics.
Germany's Project DEAL has come to an agreement with the publisher Wiley over journal access and open-access publishing, ScienceInsider reports.
Researchers uncover additional loci associated with lifespan, which the Telegraph says could be folded into a genetic test.
A Canadian panel recommends public coverage of the gene therapy Kymriah if its cost comes down, the Globe and Mail reports.
In Nucleic Acids Research this week: new accurate quantification by sequencing approach, CNV breakpoints in Plasmodium falciparum, and more.