University of Texas at Austin CRISPR-Associated Nuclease Degrades RNA, DNA to Impair Cell Growth; Promises Use in Biotech The nuclease, dubbed Cas12a2, is described in two new papers and could potentially be used in a range of biotechnological applications, including as a diagnostic. Engineered Cas9 Enzyme Less Likely to Make Off-Target Cuts, Still Efficient After analyzing Cas9 conformations at different points during mismatch cleavage, researchers developed a new enzyme to avoid such cuts. New Sanger Sequencing Dyes Could Reduce Cost While Maintaining Performance Premium An ABRF working group compared three dyes for Sanger sequencing to find that, even with their differences in price, they all performed similarly. CRISPR Study Shows Cas12a May Select DNA Target Sequences More Precisely Than Cas9 The researchers showed that Cas12a discriminates strongly against mismatches to DNA targets, leading to less off-target DNA cleavage than with Cas9. ABRF Speakers Outline Disaster Prep for Core Facilities Speakers at the Association for Biomolecular Resource Facilities annual meeting gave advice on preparing for and recovering from hurricanes. Mar 27, 2018 Research Teams Reveal Possible Roles of Cas4 in CRISPR Adaptation Jun 13, 2017 NSF Awards Grants Supporting Genomic Tool Development Dec 11, 2015 MyConnectome Study Takes 'Phenome-Wide' Approach to Understanding Brain Function Jul 15, 2015 NSF Awards Researchers $1.4M to Develop High-Quality Map of Cotton Genome Dec 5, 2014 U of Texas Transcriptome Study Reveals Gene Networks Related to Alcoholism Premium Jul 31, 2014 Genomics in the Journals: Arrays 2014.07.31 May 15, 2014 Genomics in the Journals May 15, 2014 Nov 19, 2013 Researchers Develop Circle Sequencing Scheme to Boost Base Call Accuracy Premium Nov 15, 2013 Texas Universities Get $1.3M to Pursue Cancer Omics Data Sorting, Analysis Method Mar 14, 2013 Salk Institute Using WaferGen SmartChip System in 'Nano-qPCR' Core Lab Premium Mar 14, 2013 Enzymatics, UT-Austin Develop Room Temp-Stable NGS Library Construction Kits Premium Sep 20, 2012 UT-Austin Scientist Snags $2.5M NIH Pioneer Award May 24, 2012 DARPA Awards $15.6M for Synthetic Biology Machinery, Methods Jan 31, 2012 IP Update: California Institute of Technology; Fluidigm; Life Technologies; and More Premium Oct 11, 2011 Indiana to Host Computational Core for NSF-Funded Genomics Sep 27, 2011 Bioo, Jungwoo Partner on Cancer MDx Technologies Nov 16, 2010 Researchers Use Phylogenetics to ID Sources of HIV Infections in Criminal Cases Sep 15, 2010 UT Austin Leading $3.8M Cotton Sequencing Project Nov 9, 2009 UT-Austin, Southwestern U Developing New Biomarker Screening Technology Jun 18, 2009 University of Texas Team Automates Sequence Alignment, Phylogenetic Tree Generation Load More Breaking News Simple HealthKit Raises $8M in Series A Round Top Five Articles on GenomeWeb Last Week: Quantum-Si Layoffs, UBS Coverage Initiations, More LumiraDx Secures FDA Emergency Use Authorization, UK Approval for COVID-19, Flu Test Rarity Bioscience Raises Additional €500,000 Cancer Prognoses Informed by Module-Based Approach, Study Finds The Scan UK Team Presents Genetic, Epigenetic Sequencing Method Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers. DNA Biobank Developed for French Kidney Donors, Recipients The KiT-GENIE biobank described in the European Journal of Human Genetics contains DNA samples, genotyping profiles, immune patterns, and clinical features for thousands of kidney donors or transplant recipients in Nantes, France. Cardiometabolic Disease May Have Distinct Associations With Microbial Metabolites in Blood, Gut By analyzing gut microbes in combination with related metabolites in feces and blood, researchers in Nature Communications found distinct cardiometabolic disease relationships at each site. Study Reveals New Details About Genetics of Major Cause of Female Infertility Researchers in Nature Medicine conducted a whole-exome sequencing study of mote than a thousand patients with premature ovarian insufficiency.