University of Texas at Austin GWAS of UK Biobank Participants Reveals Genetic Loci Linked to Human Skeletal Formation An AI-enabled study of X-ray images of 39,000 UK Biobank and GWAS sheds light on how humans evolved to be bipedal. CRISPR-Associated Nuclease Degrades RNA, DNA to Impair Cell Growth; Promises Use in Biotech The nuclease, dubbed Cas12a2, is described in two new papers and could potentially be used in a range of biotechnological applications, including as a diagnostic. Engineered Cas9 Enzyme Less Likely to Make Off-Target Cuts, Still Efficient After analyzing Cas9 conformations at different points during mismatch cleavage, researchers developed a new enzyme to avoid such cuts. New Sanger Sequencing Dyes Could Reduce Cost While Maintaining Performance Premium An ABRF working group compared three dyes for Sanger sequencing to find that, even with their differences in price, they all performed similarly. CRISPR Study Shows Cas12a May Select DNA Target Sequences More Precisely Than Cas9 The researchers showed that Cas12a discriminates strongly against mismatches to DNA targets, leading to less off-target DNA cleavage than with Cas9. Apr 26, 2018 ABRF Speakers Outline Disaster Prep for Core Facilities Mar 27, 2018 Research Teams Reveal Possible Roles of Cas4 in CRISPR Adaptation Jun 13, 2017 NSF Awards Grants Supporting Genomic Tool Development Dec 11, 2015 MyConnectome Study Takes 'Phenome-Wide' Approach to Understanding Brain Function Jul 15, 2015 NSF Awards Researchers $1.4M to Develop High-Quality Map of Cotton Genome Dec 5, 2014 U of Texas Transcriptome Study Reveals Gene Networks Related to Alcoholism Premium Jul 31, 2014 Genomics in the Journals: Arrays 2014.07.31 May 15, 2014 Genomics in the Journals May 15, 2014 Nov 19, 2013 Researchers Develop Circle Sequencing Scheme to Boost Base Call Accuracy Premium Nov 15, 2013 Texas Universities Get $1.3M to Pursue Cancer Omics Data Sorting, Analysis Method Mar 14, 2013 Salk Institute Using WaferGen SmartChip System in 'Nano-qPCR' Core Lab Premium Mar 14, 2013 Enzymatics, UT-Austin Develop Room Temp-Stable NGS Library Construction Kits Premium Sep 20, 2012 UT-Austin Scientist Snags $2.5M NIH Pioneer Award May 24, 2012 DARPA Awards $15.6M for Synthetic Biology Machinery, Methods Jan 31, 2012 IP Update: California Institute of Technology; Fluidigm; Life Technologies; and More Premium Oct 11, 2011 Indiana to Host Computational Core for NSF-Funded Genomics Sep 27, 2011 Bioo, Jungwoo Partner on Cancer MDx Technologies Nov 16, 2010 Researchers Use Phylogenetics to ID Sources of HIV Infections in Criminal Cases Sep 15, 2010 UT Austin Leading $3.8M Cotton Sequencing Project Nov 9, 2009 UT-Austin, Southwestern U Developing New Biomarker Screening Technology Load More Breaking News Compact Gene Editing Enzyme May Improve Success Rates of Gene Therapies People in the News at Veracyte, Invitae, Mount Sinai, InterVenn Biosciences, Applied BioCode, More New Products Posted to GenomeWeb: Qiagen, IDT, Revvity, Mission Bio, NRichDx, More FDA Releases Proposed Rule for Oversight of Laboratory-Developed Tests CStone Pharmaceuticals, Genetron Companion Diagnostic Receives NMPA Approval The Scan Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants. Small Study of Gene Editing to Treat Sickle Cell Disease In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms. Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema. Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.