University of Oxford
Osteoarthritis-Associated Variants in Retinoic Acid Synthesis Gene Point to Potential Treatment
A new study found that a drug that blocks retinoic acid metabolism could suppress mechano-inflammation in animal models of osteoarthritis.
Polygenic Risk Scores Can Differ for Same Disease in Individuals, Hampering Clinical Implementation
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The issue may lie in how the same data is analyzed to construct different PRS, posing a challenge for using and discussing the risk scores in the clinic.
Spatial Copy Number Variant Maps Shed Light on Clonal Cancer Development
Spatially resolved copy number profiles in malignant and benign tissues across organ types led to the detection of ancestral clones at seemingly cancer-free sites.
Type 2 Diabetes Multi-Ancestry GWAS Enables Risk Prediction Across Populations
With data for more than 180,800 cases and some 1.2 million controls, researchers found hundreds of genetic risk loci and developed multi-ancestry risk scores.
Elysium Health, University of Oxford Partner for Childhood Growth, Neurodevelopment Study
The New York-based aging research company will analyze DNA methylation patterns in 2,500 umbilical cord blood samples for the global Interbio-21st study.