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University of Montreal

Blood Cell Traits Linked to Individual Loci, Polygenic Contributors in International Studies

Two new papers have identified thousands of genetic loci with ties to more than two-dozen blood cell traits in individuals from up to five ancestry groups.

Polygenic Risk Scores Predict Heart Disease in French-Canadian Cohort

The two genome-wide scores to predict coronary artery disease risk, which were developed using UK Biobank data, were also valid in French-Canadians.

Proteogenomic Approach Identifies Candidate Tumor-Specific Antigens for Immunotherapies

Researchers were able to identify 40 tumor-specific antigens within two mouse cancer cell lines and seven human primary tumors using this approach.

Rare Variants Play Outsized Role in Human Height

A meta-analysis of hundreds of thousands of individuals led to several dozen rare or low-frequency variants with relatively pronounced effects on height.

Inuit Gut Microbiome Shares Features With Gut Communities From Westernized, Urban Center

A phylogenetic analysis of gut microbial communities in the Inuit population revealed broad similarities to gut microbiomes from individuals in the city of Montreal.

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The Scan

Cell Signaling Pathway Identified as Metastasis Suppressor

A new study in Nature homes in on the STING pathway as a suppressor of metastasis in a mouse model of lung cancer.

Using Bees to Gain Insights into Urban Microbiomes

As bees buzz around, they pick up debris that provides insight into the metagenome of their surroundings, researchers report in Environmental Microbiome.

Age, Genetic Risk Tied to Blood Lipid Changes in New Study

A study appearing in JAMA Network Open suggests strategies to address high lipid levels should focus on individuals with high genetic risk and at specific ages.

Study Examines Insights Gained by Adjunct Trio RNA Sequencing in Complex Pediatric Disease Cases

Researchers in AJHG explore the diagnostic utility of adding parent-child RNA-seq to genome sequencing in dozens of families with complex, undiagnosed genetic disease.