University of Michigan
Reproduction, Lifespan Show Antagonistic Pleiotropy in Genetic Analysis
Using UK Biobank data, researchers found that genetic variants linked to increased reproductive capabilities coincided with shorter lifespan in individuals of European ancestry.
Type 2 Diabetes Development Linked to GWAS-Informed Regulatory Modules
Researchers used transcriptomic and functional analyses to find regulatory modules for early-stage type 2 diabetes, focusing in on a module containing the beta cell-related gene RFX6.
Abdominal Aortic Aneurysm Genetic Study Finds Lipid Metabolism Loci, Potential Drug Target
A large genome-wide association study meta-analysis unearthed disease-associated genes and pathways and suggested PCSK9 inhibitors as a potential treatment.
Asymptomatic C. Difficile Carriers Prone to Progress to Infection in the Hospital
A longitudinal study of ICU patients found that transition from asymptomatic C. difficile carriage to full-blown infection was far more common than transmission between patients.
Somatic Mutations in Noncoding Regions Common in Adult Blood Cells
A whole-genome sequencing analysis of blood samples from 43,693 people found 7,131 non-oncogenic somatic mutations in at least 50 individuals.