University of Michigan
Global Biobank Meta-Analysis Initiative Brings Greater Diversity to Global GWAS
The initiative combines biobank data from around the globe to provide deeper and more representative insights into the genetics of human health.
Heart Disease Genes Flagged by Rare Variant Analysis of Spontaneous Coronary Artery Dissection
With exome sequencing, researchers found risky rare variants in genes involved in vascular connective tissue disease, related monogenic conditions, or past association studies.
Genotype Imputation From Array Data Can Approximate Sequencing in Some Cases, Study Finds
Imputation quality varies by reference panel, genotype array, and other factors, the researchers found, and the approach is currently not suitable for clinical use.
New TWAS Method Helps Analyze Data From Multiple Genetic Ancestries
Researchers found that their "multi-ancestry transcriptome-wide analysis" (METRO) approach could pick up complex trait associations using gene expression and GWAS data.
Polygenic Risk Scores for Breast, Prostate Cancer Adaptable for Cross-Ancestry Use, Study Shows
The researchers said the approach could be a short-term measure while genetic studies of more diverse ancestral populations are performed.