University of Melbourne
End-Stage Ovarian Cancer Marked by Rampant Treatment Resistance, Multiple Clones
By profiling multiple tumors per patient, researchers found pronounced polyclonal disease and diverse resistance mechanisms in end-stage high-grade serous ovarian carcinoma.
Plague Pathogen Population History Informed by Integrative Analysis
Researchers found that genetic analyses of Yersinia pestis genomes alone could not sufficiently track the slow-mutating microbes, which have an unstable molecular clock.
Denisovan DNA Detected in Papuan Immune Gene Regulatory Regions
Researchers mapped archaic and non-archaic variants in 56 Papuan genome sequences, tracking down Denisovan variants at regulatory elements linked to cells with immune roles.
An Australian team of researchers designed one-page reports for families that were implemented as part of a national pediatric ultra-rapid genomic testing program.
Study Unearths Features Found in Long-Term Survivors of Advanced Ovarian Cancer
Researchers examined genetic, tumor mutation, and immune features among individuals surviving at least a decade after an advanced ovarian cancer diagnosis.