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Using data for more than a million individuals with or without insomnia, two independent research teams tracked down associated risk loci and explored their functional effects.

A handful of exposures to ultraviolet radiation was enough to induce the melanoma-associated signature within a mouse model.

Researchers used fine mapping and other approaches to prioritize proposed coding and non-coding causal variants at rheumatoid arthritis- and type 1 diabetes-linked loci.

These differentially variable positions appear to implicate stress response in rheumatoid arthritis development and possibly in other autoimmune conditions.

A heterozygous variant upstream of the BRCA1 translation start site was uncovered in all individuals in these two families with hypermethylated BRCA1 promoters.

This Week in PLOS

In PLOS this week: non-coding RNA function in yeast, transcriptomic profiles of malaria parasites, and more.

Analysis of ancient DNA from mummies known as the Two Brothers finds they are half-brothers, according to Science News.

An integrated analysis of 30 soil microbiome datasets suggests that common bacterial taxa may be less useful ecological indicators compared to much rarer taxa.

Clearer Risk

The Guardian reports that a new genetic risk test for breast cancer may give clearer risk estimates.

In a retrospective cohort study of Lynch syndrome patients, researchers found that cancer onset varied both by which gene was mutated and how it was altered.

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Bloomberg reports that the DNA-for-cash deal reported in Kentucky might be a more widespread scam.

St. Jude Children's Research Hospital scientists have treated infants with X-linked severe combined immunodeficiency using gene therapy in an early phase study.

St. Louis Public Radio reports that some African Americans are turning to DNA ancestry testing to help guide genealogical searches.

In Nature this week: a genomic analysis of the snailfish Pseudoliparis swirei, ancient DNA analysis gives insight into the introduction of farming to England, and more.