University of Manchester
Small Cell Lung Cancer Detection, Classification Achieved Using Cell-Free DNA Methylation
With a bisulfite-free sequencing method, researchers showed that they could identify and characterize SCLC based on circulating cell-free tumor DNA in blood samples.
Type 2 Diabetes Multi-Ancestry GWAS Enables Risk Prediction Across Populations
With data for more than 180,800 cases and some 1.2 million controls, researchers found hundreds of genetic risk loci and developed multi-ancestry risk scores.
Kidney Omics Study Sheds Light on Blood Pressure Mechanisms
Combining genomic, transcriptomic, and epigenomic profiles from human kidneys with GWAS results, investigators discovered blood pressure targets and regulators.
Endometrial Cancer Study Identifies 24 Variants Linked to Disease Predisposition
University of Manchester and University of Cambridge researchers found SNPs in genes involved in cell survival, estrogen metabolism, and transcriptional control.
Gene Panel Finds Pathogenic Variants Missed by Standard Tests in 5 Percent of Familial Cancer Cases
The researchers profiled 44 cancer-related genes in 191 individuals with familial breast cancer, colorectal cancer, or other forms of early-onset cancer.