University of Manchester

A handful of exposures to ultraviolet radiation was enough to induce the melanoma-associated signature within a mouse model.

Researchers used fine mapping and other approaches to prioritize proposed coding and non-coding causal variants at rheumatoid arthritis- and type 1 diabetes-linked loci.

These differentially variable positions appear to implicate stress response in rheumatoid arthritis development and possibly in other autoimmune conditions.

A heterozygous variant upstream of the BRCA1 translation start site was uncovered in all individuals in these two families with hypermethylated BRCA1 promoters.

This Week in PLOS

In PLOS this week: non-coding RNA function in yeast, transcriptomic profiles of malaria parasites, and more.

Analysis of ancient DNA from mummies known as the Two Brothers finds they are half-brothers, according to Science News.

An integrated analysis of 30 soil microbiome datasets suggests that common bacterial taxa may be less useful ecological indicators compared to much rarer taxa.

Clearer Risk

The Guardian reports that a new genetic risk test for breast cancer may give clearer risk estimates.

In a retrospective cohort study of Lynch syndrome patients, researchers found that cancer onset varied both by which gene was mutated and how it was altered.

A new analysis finds that collagen thought to have belonged to Tyrannosaurus rex was likely contamination, the International Business Times reports.

Pages

Publication of He Jiankui's work on gene-edited infants would raise ethical concerns for journals, Wired and others report.

The New York Times reports that evidence linking trauma in one generation to epigenetic effects that influence subsequent generations may be overstated.

ScienceInsider reports that US National Institutes of Health researchers were told in the fall they could not obtain new human fetal tissue.

In PNAS this week: skin pigmentation evolution among KhoeSan, biomarkers for dengue virus progression, and more.