With targeted sequence data on more than 500 cases of the lymphatic fluid accumulation condition, researchers found and explored lymphedema-related ANGPT2 mutations.
Transcriptomic and multi-omic data spanning more than 10,000 samples helped map "immunogenomic" interactions that may inform treatment outcomes and targets.
Mitochondrial sequences suggest some haplogroups found in Finland today arrived in the region pre-Iron Age, though population distributions have shifted.
In PLOS this week: missense variant linked to hereditary leukodystrophy in dogs, genetic variants associated with drug-induced interstitial lung disease, and more.
Investigators pooled older and new data from the Prospective Lynch Syndrome Database, tracking outcomes for different mutations across age and gender groups.
