University of Helsinki
Common Disease Polygenic Risk Scores Show Poor Cross-Ancestry Performance
Using data from six international cohorts, researchers explored cross-ancestry transferability of PRSs for heart disease, type 2 diabetes, breast cancer, and prostate cancer.
Ovarian Cancer Chemotherapy Resistance Linked to Stress-Associated Gene Expression Features
By sequencing RNA in pre- and post-treatment cancer samples, researchers saw tumor and microenvironment features coinciding with poor neoadjuvant chemotherapy response.
Migraine GWAS Points to Subtype-Specific Loci, Potential Mechanisms
Researchers linked migraine risk to 123 loci, including risk variants not found in the past and loci implicated in migraine subtypes.
Finnish Population Genetic Analysis Reflects Recent Historical Events
With genetic data from nearly 18,500 Finnish individuals, investigators retraced fine-scale population patterns in the country over several decades.
Called Intervene, the project will use genomic and health data from biorepositories along with machine learning methods to develop new clinical predictive tools.