University of Groningen Consortium Catalogs Variants Affecting Blood Gene Expression Members of the eQTLGen Consortium turned to data for almost 31,700 individuals to define local and distant expression quantitative trait loci affecting gene expression in the blood. Microbial Fingerprints, Health Insights Gleaned From Individual Gut Microbiome Dynamics With gut microbiome data for individuals sampled four years apart, researchers saw stable and unstable gut microbial species, including those linked to host phenotypes. Genetic Variants Influence Cardiac Features Captured By Electrocardiograms, Study Finds The University of Groningen-led team further uncovered variants associated with risk of dilated cardiomyopathy. CRISPR Researchers Use Cas12a to Develop Multiplex Genome Engineering Platform The team used this system to perform orthogonal and multiplexed genome engineering of endogenous targets using up to 25 individual CRISPR RNAs. Single-Cell Lung Atlases Reveal New Cell Types, Asthma-Related Alterations With RNA sequence data on thousands of individual lung cells, researchers fleshed out new and known cell clusters, before digging into cell state and cellular interaction changes in asthma. Dec 19, 2018 Inflammatory Bowel Disease, Irritable Bowel Syndrome Show Differences in Gut Microbiomes Nov 1, 2018 Chronic Infection Genetic Risk Loci Point to Immune, Metabolic Pathways Sep 24, 2018 Genetics, Gut Microbes Linked to Blood Levels of Cardiovascular Disease-Related Proteins Jun 27, 2018 Lifestyle, Genetics Independently Predict Cardiovascular Disease, Diabetes Risk Mar 1, 2018 Heart Rate GWAS Provides Insight on Exercise Response, Recovery Oct 31, 2016 Resting Heart Rate Linked to Overall Mortality Through Dozens of Genetic Loci Oct 7, 2016 Haplotype-Resolved Structural Variant Map Highlights Complexity of Human Genome Sep 23, 2016 Strand-Seq Analytical Pipeline Developed for Direct Haplotyping Premium Jun 3, 2016 Tumor Karyotype Heterogeneity May Predict Outcomes, Inform Treatment Options, Dutch Team Finds Premium May 19, 2016 CRISPR/Cas9 Takes Root in Core Facilities Worldwide Premium May 18, 2016 Netherlands Considers Patients' Preferences, Feasibility of Expanded Carrier Screening Premium Apr 28, 2016 Gut Microbiome Makeup Influenced by Medication Use, Other Factors Jan 27, 2016 Seagrass Genome Elucidates How Flowering Plant Re-adapted to Marine Environment Sep 9, 2013 Study Links GWAS Risk Loci to Distant Gene Expression Oct 27, 2009 In Some European Clinical Cytogenetic Labs, Arrays Have Become Primary Sample-Analysis Tool Premium Feb 4, 2009 Ovarian Cancer Prognostic Signature Reveals Key Pathways Breaking News NIH Earmarks $170M for All of Us Program's Personalized Nutrition Study Taiwanese Firm's IP Asserted in Suit Against Pacific Biosciences Found Partially Unpatentable In Ongoing False Advertising Suit, Judge Allows Natera Counterclaims Against Guardant Health Centogene Strikes Rare Disease Target Discovery Deal With Insilico Medicine Dilated Cardiomyopathy Gene Mutations Point to Possible Therapeutic Strategy Ginkgo Bioworks Acquires Massachusetts COVID-19 Testing Firm The Scan Transplant Tests Edited Pig Kidneys The Associated Press reports a University of Alabama-Birmingham team transplanted genetically modified pig kidneys into a brain-dead human patient. UK Changes Some Gene-Edited Crop Rules A new law may enable gene-edited crops to be sold in the UK within about five years, New Scientist says. Pill Works Against Omicron in Lab Pfizer's antiviral pill to treat SARS-CoV-2 appears to work against the Omicron variant, the Wall Street Journal reports. Nature Papers Find Genetic Risk Factor for Smell, Taste Loss in COVID-19; Analyze TB Granulomas In Nature this week: genome-wide association study find locus linked to the risk COVID-19 patients losing their sense of taste or smell, and more.