University of Geneva Metagenomics Enables Researchers to Uncover Pathogens, Drug Resistance Genes Metagenomics can help researchers and clinicians uncover sources of infectious disease and discern whether pathogens are resistant to antimicrobials. KRAS Mutations Revealed in Rare Vascular Brain Condition Researchers identified somatic KRAS mutations in affected tissue from more than 60 percent of people with sporadic arteriovenous malformations of the brain. Saphetor Adds Geneva University Hospitals to Client List for Variant Annotation Platform Premium HUG's genetic medicine arm will use Saphetor's software and variant knowledgebase in clinical projects focused on developmental and neurological disorders. Researchers Uncover Additional Drivers, Pathways Involved in Basal Cell Carcinoma An international team has uncovered roles for MYCN, PTPN14, and LATS1 mutations in the development and progression of skin basal cell carcinoma. Study of Twins Starts Unraveling Genetic, Environmental Contributors to Gene Regulation Sep 16, 2013 Widespread Variation Affects Regulation of Most Human Genes, Study Finds Dec 27, 2011 Melanoma Exome Sequencing Studies Find Recurrent Somatic Mutations in Kinase Family Sep 9, 2011 Swiss Team Explores Effects of Epistasis between Coding and Regulatory Variants Jun 7, 2011 Swiss Organizations Team up with Roche in Translational Research Mar 4, 2010 AB Sciex, U of Geneva to Collaborate on Mass Spec Workflows Jul 30, 2009 Team IDs Cell Type-Specific Expression Effects for Regulatory Variants Breaking News Mount Sinai, Regeneron Launch Sequencing Project to Augment Genetics-Based Precision Medicine Heart Dysfunction Insights Drawn From Age-Related Cardiomyocyte Mutations People in the News at Oncocyte, OraSure, Illumina Ventures, More New Products Posted to GenomeWeb: Thermo Fisher, Bio-Rad, Qiagen, More Guardant Health, Thermo Fisher Scientific Tests Approved as CDx to Enhertu in Lung Cancer The Scan Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations. Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper. Infectious Disease Tracking Study Compares Genome Sequencing Approaches Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available. LINE-1 Linked to Premature Aging Conditions Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.