University of Cincinnati

This Week in PNAS

In PNAS this week: genome and transcriptome sequencing study of tobacco plants, molecular effects of cytochrome c oxidase mutations, and more.

In blood samples from infected individuals, a seven-gene signature apparently distinguishes between bacterial and viral culprits, a distinction important to antibiotic use.

Recently established biomedical informatics divisions at the hospital support projects like Bench-to-Bassinet and the Longitudinal Pediatric Data Resource.

Scientists will look for genetic causes of craniofacial asymmetries and loss of skin pigmentation in a cave-dwelling fish that could shed light on similar conditions in humans.

The goal is to identify patient-specific rearrangements in the primary tumor, and then check for the presence of that rearrangement in the patient's blood during treatment in order to determine tumor progression and monitor therapy response.

In the deal with the University of Cincinnati, Drug Discovery Center, Proteros will provide biotechnology and drug firms access to UC DCC's ultra-high throughput and high-content screening platform along with a library of more than 340,000 drug-like compounds.

The technique is based on a MALDI triple-quadrupole platform and exploits the selective multiple-reaction monitoring transition features of the instrument to circumvent problems resulting from interference that can plague existing methods.

The change is expected to help the state translate the approximately $1.5 billion in research generated annually at Ohio's public higher education institutions into goods and services and create jobs by "substantially increasing" the number of university startups in the state, an official said.

Under the Phenotypic Drug Discovery program, researchers from academia or biotech submit candidate compounds in specific therapeutic areas for Lilly to evaluate and profile. Participating organizations retain full IP rights to the compounds, but Lilly receives first rights to negotiate a broader collaboration or licensing agreement.

The University of Cincinnati will use the funds to start a clinical and translational research center and to collaborate with hospitals.

New Mexico is re-doing its proposed science education standards after criticism, the Associated Press reports.

Agbio executives say gene editing will speed up breeding efforts, according to the Wall Street Journal.

La Trobe University's Jenny Graves has won the $250,000 Prime Minister's Prize for Science, the Guardian reports.

In Cell this week: post-treatment changes to melanoma genome, multi-omics analysis of muscle-invasive bladder cancer, and more.