University of Cincinnati

This Week in PNAS

In PNAS this week: genome and transcriptome sequencing study of tobacco plants, molecular effects of cytochrome c oxidase mutations, and more.

In blood samples from infected individuals, a seven-gene signature apparently distinguishes between bacterial and viral culprits, a distinction important to antibiotic use.

Recently established biomedical informatics divisions at the hospital support projects like Bench-to-Bassinet and the Longitudinal Pediatric Data Resource.

Scientists will look for genetic causes of craniofacial asymmetries and loss of skin pigmentation in a cave-dwelling fish that could shed light on similar conditions in humans.

The goal is to identify patient-specific rearrangements in the primary tumor, and then check for the presence of that rearrangement in the patient's blood during treatment in order to determine tumor progression and monitor therapy response.

In the deal with the University of Cincinnati, Drug Discovery Center, Proteros will provide biotechnology and drug firms access to UC DCC's ultra-high throughput and high-content screening platform along with a library of more than 340,000 drug-like compounds.

The technique is based on a MALDI triple-quadrupole platform and exploits the selective multiple-reaction monitoring transition features of the instrument to circumvent problems resulting from interference that can plague existing methods.

The change is expected to help the state translate the approximately $1.5 billion in research generated annually at Ohio's public higher education institutions into goods and services and create jobs by "substantially increasing" the number of university startups in the state, an official said.

Under the Phenotypic Drug Discovery program, researchers from academia or biotech submit candidate compounds in specific therapeutic areas for Lilly to evaluate and profile. Participating organizations retain full IP rights to the compounds, but Lilly receives first rights to negotiate a broader collaboration or licensing agreement.

The University of Cincinnati will use the funds to start a clinical and translational research center and to collaborate with hospitals.

Researchers find that a personalized medicine approach could help people who experience pain while taking statins, New Scientist reports.

US National Science Foundation is continuing its responsible research conduct training policy despite its flaws, ScienceInsider reports.

A CRISPR-themed meeting explored how the tool could and should be used, Wired reports.

In Science this week: database of proteins' effects on cancer, targeted error correction sequencing, and more.