University of Chicago
Breast, Ovarian Cancer Contributors Uncovered in TWAS Studies
In a pair of new studies, independent research teams used distinct transcriptome-wide association study approaches to find breast and ovarian cancer contributors.
Study Spells Out Smoking-Related DNA Methylation Changes in Lung, Colon Tissue
By profiling cytosine methylation patterns in samples from nine tissue types, researchers focused in on gene regulatory changes associated with smoking.
Mexican Population Studies Provide Ancestry, Complex Trait Clues
Teams teased out ancestry, allele frequency, imputation, and genetic risk variant profiles for populations using data from the Mexican Biobank and Mexico City Prospective Study.
Study Finds Mechanism Linking Noncoding Risk Locus, Disease-Related Cellular Phenotypes
Using ATAC-seq and CRISPR-Cas9 editing in cell lines, researchers established a link between a noncoding schizophrenia risk locus and cellular phenotypes.
Female-Specific Fat Distribution Gene, Regulatory Variant Emerge from Gene Expression Study
With transcriptome-wide association studies of BMI and waist-to-hip ratio adjusted for BMI, researchers began to untangle the genetics of fat distribution.