University of Cambridge Type 1 Diabetes Onset Preceded by Gene Expression Changes Investigators identified natural killer cell-related expression signatures in blood samples from children who later developed type 1 diabetes or islet autoimmunity. Polygenic Risk Score Reporting Standards Developed An international team came up with a 22-point framework for developing, validating, and reporting polygenic risk scores used for predicting traits and conditions. Childhood Cancer Study Reveals Pan-Neuroblastoma Cell State The researchers said this unexpected homogeneity in the cellular identity of neuroblastoma could lead to the development of targeted treatments. Breast Cancer Risk Gene Associations Refined in Large-Scale Studies Two new studies revealed the prevalence of pathogenic variants in breast cancer-related genes, while highlighting genes that may be most informative in the clinic. Single-Cell Transcriptome Study Links Gut Development, Pediatric Crohn's Disease Researchers saw transcription factor similarities between developing human intestinal cells and cells from pediatric Crohn's disease cases. Nov 23, 2020 Rare Variant Study Suggests Blood Pressure Traits May Have Ties to Development, Heart Conditions Sep 16, 2020 Viking Age Human Migrations Untangled Through Ancient DNA Analysis Sep 8, 2020 Early Copy Number Changes Predict Progression of Barrett's Esophagus to Esophageal Cancer Sep 3, 2020 Blood Cell Traits Linked to Individual Loci, Polygenic Contributors in International Studies Jul 21, 2020 Less Painful Childbirth Associated With Rare Variant in Ion Channel Gene Jun 25, 2020 Inivata Demonstrates Potential of ctDNA Assay for Cancer Recurrence, MRD Applications Premium Jun 24, 2020 Whole-Genome Sequencing Study Identifies Four Novel Disease-Causing Variants Jun 23, 2020 Patient-Specific ctDNA Detection Method Could Improve MRD Monitoring for Cancer Recurrence Premium Jun 11, 2020 Diversity Problem Hinders Adoption of Polygenic Risk Scores, According to ESHG Panel Jun 8, 2020 Microbiotica, Cambridge Researchers to Study Microbiome Impact on Immunotherapy Response May 7, 2020 Primary Immunodeficiency Study Highlights Monogenic, Common Variant Disease Contributors Apr 8, 2020 Novacyt, AstraZeneca, GSK, University of Cambridge Partner to Increase SARS-CoV-2 Testing in UK Mar 26, 2020 Positive Selection Influences Clonal Hematopoiesis That Occurs in Blood During Aging Mar 25, 2020 UK COVID-19 Sequencing Consortium to Reveal Viral Spread, Evolution Mar 23, 2020 UK COVID-19 Sequencing Consortium Launches With £20M in Government, Wellcome Trust Funding Feb 18, 2020 Endometrial Cancer Study Identifies 24 Variants Linked to Disease Predisposition Dec 23, 2019 New Genetic Score Predicts Stroke Risk Better Than Established Risk Factors Nov 8, 2019 Wellcome Sanger Institute Commits $11.8M to Darwin Tree of Life Project Oct 31, 2019 Uganda Genome Resource Sheds Light on Population History, Enables New Association Studies Oct 31, 2019 New Early Cancer Detection Alliance to Trial Bevy of New Technologies and Tests Premium Load More Breaking News Enzo Biochem, CLX Health Partner to Support COVID-19 Testing for International Travel Type 1 Diabetes GWAS, Fine-Mapping Leads to New Genetic Loci, Potential Drug Targets LSU Health Sciences Center Wins $2.4M to Lead SARS-CoV-2 Variant Sequencing Program NanoString Technologies, Parker Institute for Cancer Immunotherapy Partner on Cell Therapy Project BGI Americas Collaborating With Champions Oncology on Proteomic Cancer Research Personal Genome Diagnostics Inks Cancer Genomic Profiling Deal with Duke University Health System The Scan Missed Early Cases A retrospective analysis of blood samples suggests early SARS-CoV-2 infections may have been missed in the US, the New York Times reports. Limited Journal Editor Diversity A survey finds low diversity among scientific and medical journal editors, according to The Scientist. How Much of a Threat? Science writes that need for a provision aimed at shoring up genomic data security within a new US bill is being questioned. PNAS Papers on Historic Helicobacter Spread, Brain Development, C. difficile RNAs In PNAS this week: Helicobacter genetic diversity gives insight into human migrations, gene expression patterns of brain development, and more.