University of Cambridge

The UK developers believe that their device has the potential for multiplex testing at the point of care using solid-state nanopore sensing with DNA probes.

The researchers studied edits generated by more than 40,000 gRNAs and gathered data for more than 109 mutational outcomes to create the software.

Data for nearly 306,500 individuals revealed the impact of independent lifestyle and genetic factors on stroke risk over roughly seven years of follow up.

Researchers saw frequent somatic mutations in esophageal tissue from nine individuals, including mutations under positive selection in 14 oncogenes.

According to the researchers, led by a team at the University of Cambridge, detecting somatic brain mutations in patients during their life may increase diagnostic precision and lead to new therapies.

This Week in Science

In Science this week: series of reviews about gene modification, and more.

In Nucleic Acids Research this week: database of methylation quantitative trait loci in tumors, database of ancient mitochondrial genomes, and more.

For the first time, researchers used mitochondrially targeted zinc-finger nucleases to induce specific elimination of mutant mtDNA across the heart.

An analysis of naturally occurring alleles in the lipoprotein lipase pathway found that they and LDL-C-linked alleles affect disease risk independently.

By sequencing 72,501 individual kidney cells, researchers saw some shared transcriptional patterns in kidney cancers and developing or adult kidneys.

Pages

A genome-wide association study highlights a potential role for hair follicles in acne risk, according to New Scientist.

Newsday reports that breast cancer genetic testing guidelines for are out of date and may miss individuals.

In Cell this week: gene editing-based strategy to screen for immune system regulators, ancient plague patterns, and more.

Publication of He Jiankui's work on gene-edited infants would raise ethical concerns for journals, Wired and others report.