University of Cambridge
Type 1 Diabetes Onset Preceded by Gene Expression Changes
Investigators identified natural killer cell-related expression signatures in blood samples from children who later developed type 1 diabetes or islet autoimmunity.
Polygenic Risk Score Reporting Standards Developed
An international team came up with a 22-point framework for developing, validating, and reporting polygenic risk scores used for predicting traits and conditions.
Childhood Cancer Study Reveals Pan-Neuroblastoma Cell State
The researchers said this unexpected homogeneity in the cellular identity of neuroblastoma could lead to the development of targeted treatments.
Breast Cancer Risk Gene Associations Refined in Large-Scale Studies
Two new studies revealed the prevalence of pathogenic variants in breast cancer-related genes, while highlighting genes that may be most informative in the clinic.
Single-Cell Transcriptome Study Links Gut Development, Pediatric Crohn's Disease
Researchers saw transcription factor similarities between developing human intestinal cells and cells from pediatric Crohn's disease cases.