University of Cambridge

Using genome-wide association and targeted sequencing approaches, research teams continue to tally up genetic contributors and candidate genes in breast cancer.

Investigators saw muted negative selection against mutations in genomic data for more than 7,600 tumors, while mining positive selection patterns for cancer driver clues.

Several studies describe a new Neanderthal genome, Neanderthal sequence effects on human traits, and ancient hunter-gatherer population social structure clues.

Change Is Hard to Do

Genetic disease risk information doesn't always spur people to make healthy lifestyle changes, according to the Associated Press.

In a genome-wide association study, a Cambridge University-led research team linked 16 loci to grip strength, a proxy for muscle fitness.

This Week in PNAS

In PNAS this week: archaeal evolutionary patterns; early life stress, HDAC1, and genetic susceptibility to schizophrenia; and more.

The team performed a gene expression analysis to discover the new loci, bringing the total number of known risk loci associated with CAD to 73.

The company plans to outlicense the assay, developed using a custom Affymetrix microarray, to an interested partner.

The researchers traced the expression of related genes to neural tissues and noted a link between puberty timing and cancer risk.

A comparison of unstimulated and stimulated CD4+ T cells from young and old mice in two subspecies showed rising cell-to-cell expression variability with age.

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A research duo estimates in PLOS One the number of papers that have used misidentified cell lines.

UK's National Institute for Health and Care Excellence approves GlaxoSmithKline's SCID gene therapy despite cost.

Science reports that Brazilian researchers are petitioning for the reversal of budget cuts.

In PLOS this week: gene flow patterns in common ash, guidelines for using morpholinos in zebrafish, and more.