University of California Taproot Health, Five Cancer Centers Agree to Conduct Precision Oncology Master Trial, Share Data Within the master observational trial, the organizations have agreed to prospectively collect real world data and ultimately build a national oncology database. Ancient DNA Sheds New Light on Human Migrations in the Americas Three studies encompassing dozens of ancient genomes are offering a closer look at complex historical population spread in North, Central, and South America. New Mouse Models for Late-Onset Alzheimer's Disease May Advance Biomarker, Drug Discovery Premium Researchers used CRISPR to engineer mice that have multiple genetic variants associated with late-onset AD to facilitate research into biomarkers and treatments. Mammoth Biosciences Developing CRISPR-Based Disease Detection for At-Home, Hospital Use Premium The technology behind Mammoth's platform bears a striking resemblance to the CRISPR-based SHERLOCK platform developed by researchers at the Broad Institute. CRISPR Patents Must Be 'Reined In,' Experts Say A lawyer and a scientist say the best result in the CRISPR patent fight would be narrow patents that prevent anyone from controlling downstream innovation. Aug 23, 2017 IBM, Broad Institute to Map Human Microbiome on World Community Grid Aug 23, 2017 Autism Appears Overrepresented in Certain Mitochondrial Haplogroups Jun 7, 2017 UC Health to Have Expanded Access to GeneDx Tests Mar 17, 2016 Researchers Use CRISPR-based Method to Track RNA In Vivo Feb 25, 2016 US Healthcare Organizations Apply for Chance to Recruit 1M-Volunteer Precision Medicine Cohort Premium Aug 13, 2015 Researchers Sequence Challenging Gene-Rich Portions of Barley Genome Premium Jul 22, 2015 UC Santa Cruz Genomics Institute Awarded $2M Grant to Complete Human Genetic Variation Map May 28, 2015 Q&A: Atul Butte on New Roles at UCSF's Computational and Clinical Informatics Centers Premium Apr 14, 2015 California Launches Precision Medicine Initiative Feb 24, 2015 Oxford Nanopore Expands MinIon Early-Access Program as Users Present, Publish Early Results Nov 11, 2014 qPCR-based Assay Can Identify Kidney Transplant Patients at High Risk of Rejection, Researchers Say Aug 12, 2014 IP Watch: DuPont, Ibis Biosciences, Hitachi, Others Win US Patents Premium Jul 31, 2014 Black Truffle Methylome Reveals Regulation of Transposable Elements Jun 24, 2014 IP Roundup: Siemens, Affymetrix, Akonni, University of California, LLNL Premium May 16, 2014 UC Riverside Gets $600K NIH Grant to Support Big Data Research Apr 1, 2014 IP Roundup: Aushon Biosystems, U of California, Agilent, Affymetrix, Philips, and Ajjer Premium Jan 22, 2014 In Partnership with UCSF, Quest to Expand its Integrated Diagnostics Vision Premium Jan 9, 2014 Quest, UCSF Collaborate on Precision Medicine Nov 12, 2013 Teams Detect Base Methylation Using Nanopores; Biological DNA Concentrated Near Pores Is Next Premium Nov 12, 2013 Microwell-based Single Cell Sequencing Technique Reduces Amplification Bias Premium Load More Breaking News Centogene Strikes Rare Disease Target Discovery Deal With Insilico Medicine Dilated Cardiomyopathy Gene Mutations Point to Possible Therapeutic Strategy Ginkgo Bioworks Acquires Massachusetts COVID-19 Testing Firm Mainz Biomed Taps DCN Dx to Aid European Study of Enhanced ColoAlert Assay Parse Biosciences Partners With Research Instruments for Southeast Asia Distribution Thermo Fisher, Oncocyte Ink Development, Comarketing Deal for Cancer IVDs The Scan And a Fourth? A fourth dose of the Pfizer-BioNTech SARS-CoV-2 vaccine in an Israeli study increased antibody levels but did not prevent Omicron variant infections, according to the Financial Times. For Better Science Software A virtual institute funded by former Google CEO Eric Schmidt's philanthropy aims to lure software engineers to academia, Science reports. Recommendation Explanations The New York Times writes that the US Centers for Disease Control and Prevention is straining to both make and explain decisions based on limited information. Genome Research Papers on De Novo Mutation Rates, Polyploid Genotyping, Oncogene Epigenomic Translocation In Genome Research this week: de novo mutations rates in hemoglobin subunits, analysis of variant calling methods for polyploid plants, and more.