University of Alabama at Birmingham
Molecular Features Behind Brain Connection Variation Uncovered in Integrated Analysis
Researchers linked post-mortem protein and gene expression features to variation in brain connections and structures between individuals.
Individuals at enhanced polygenic risk of high systolic blood pressure had increased treatment resistance risk and less pronounced response to chlorthalidone in a new study.
Gout GWAS Highlights Inflammatory Pathway Contributors
With genome-wide association analyses and meta-analyses, researchers identified gout-associated loci, genes, and pathways, pointing to possible treatment options.
Scores focused on the biochemical pathways associated with disease and pairing these scores with other risk assessments could improve predictive value, the data showed.
'All of Us' Sequencing Data Links Titin Mutations, Heart Conditions in African Ancestry Individuals
As in Europeans, a specific type of titin gene mutation increased atrial fibrillation, dilated cardiomyopathy, and heart failure risk, pointing to the potential importance of testing.